Evidence map›Paper›PMID 40558201›Full record

ArticleAntibiotics (Basel, Switzerland)2025

Investigation of Therapeutic Efficacy of Intravesical Tigecycline Administration in Rats with Cystitis Induced by Extensively Drug-Resistant (XDR), Tigecycline-Sensitive

Cihan Yüksel, Işıl D Alıravcı, Murat Koşan, Sinem Esen, Sevinç Yenice Aktaş, Neslihan Kaya Terzi, Ahmet Ali Berber, Sevil Alkan, Selçuk Kaya

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cihan YükselDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Çanakkale Onsekiz Mart University, 17000 Çanakkale, Turkiye.ORCID 0000-0002-6861-9163
Işıl D AlıravcıDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Çanakkale Onsekiz Mart University, 17000 Çanakkale, Turkiye.
Murat KoşanDepartment of Urology, Faculty of Medicine, Çanakkale Onsekiz Mart University, 17000 Çanakkale, Türkiye.
Sinem EsenDepartment of Medical Microbiology, Faculty of Medicine, Çanakkale Onsekiz Mart University, 17000 Çanakkale, Türkiye.ORCID 0000-0002-4845-7910
Sevinç Yenice AktaşDepartment of Medical Microbiology, Faculty of Medicine, Çanakkale Onsekiz Mart University, 17000 Çanakkale, Türkiye.
Neslihan Kaya TerziDepartment of Medical Pathology, Faculty of Medicine, Çanakkale Onsekiz Mart University, 17000 Çanakkale, Türkiye.ORCID 0000-0001-8184-4691
Ahmet Ali BerberVocational School of Health Services, Çanakkale Onsekiz Mart University, 17000 Çanakkale, Türkiye.ORCID 0000-0002-2036-6929
Sevil AlkanDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Çanakkale Onsekiz Mart University, 17000 Çanakkale, Turkiye.ORCID 0000-0003-1944-2477
Selçuk KayaDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Çanakkale Onsekiz Mart University, 17000 Çanakkale, Turkiye.

Funding

Canakkale Onsekiz Mart Universitesi Tip Fakultesi Hastanesi TTU-2024-4782
6 · The paper itself

Abstract

backgroundThis study aimed to evaluate the therapeutic efficacy of intravesical tigecycline administration in a rat model of cystitis induced by a tigecycline-sensitive, extensively drug-resistant (XDR)

methodsThirty-six female Wistar albino rats were inoculated intravesically with XDR

resultsOn day 5, microbiological clearance was significantly higher in tigecycline-treated groups compared to controls (

conclusionsIntravesical tigecycline demonstrated microbiological efficacy against XDR

Indexed as

Acinetobacter baumanniigenotoxicityintravesical therapyrat modeltigecyclineXDR

Identifiers

PMID40558201
PMCPMC12189304

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.