Design and Synthesis of Hybrid Compounds for Potential Treatment of Bacterial Co-Infections: In Vitro Antibacterial and In Silico Studies.

Vuyolwethu Khwaza, Opeoluwa O Oyedeji, Eric Morifi, Mutshinyalo Nwamadi, Thierry Youmbi Fonkui, Derek Tantoh Ndinteh, Blessing A Aderibigbe

Abstract read

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In one paragraph

Article in Antibiotics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Recent Advances in the Development of Selected Triterpenoid-Based Hybrid Molecules and Their Antimicrobial Activities: A Review.Antibiotics (Basel, Switzerland) · 2026
Review
Heteroaromatic Hybrid Benzimidazole/Oxadiazole (BZ/OZ) Ligand and Its Sm(III) Complex: Study of Their Antibacterial Activity, Toxicological Prediction and Interaction with Different Model Membranes.Biomolecules · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vuyolwethu KhwazaDepartment of Chemistry, Alice Campus, University of Fort Hare, Alice 5700, South Africa.ORCID 0000-0003-4875-1535

Opeoluwa O OyedejiDepartment of Chemistry, Alice Campus, University of Fort Hare, Alice 5700, South Africa.ORCID 0000-0002-1240-3718

Eric MorifiMass Spectrometry Division, School of Chemistry, University of Witwatersrand, Johannesburg 2000, South Africa.

Mutshinyalo NwamadiDepartment of Chemistry, Auckland Park Campus, University of Johannesburg, Johannesburg 2092, South Africa.

Thierry Youmbi FonkuiDepartment of Biotechnology, Doornfontein Campus, University of Johannesburg, Johannesburg 2028, South Africa.

Derek Tantoh NdintehDepartment of Chemical Sciences, Doornfontein Campus, University of Johannesburg, Johannesburg 2028, South Africa.

Blessing A AderibigbeDepartment of Chemistry, Alice Campus, University of Fort Hare, Alice 5700, South Africa.ORCID 0000-0003-1157-7481

Funding

Govan Mbeki Research and Development Council GMRDCSouth Africa Medical Research Council SAMRC

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

antibacterialco-infectionCOVID-19hybrid compoundsin silico studiesSwissADMEsynthesis

Identifiers

PMID40558172

DOI10.3390/antibiotics14060582

PMCPMC12542292

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.