Evidence map›Paper›PMID 40558104›Full record

ArticleAntibodies (Basel, Switzerland)2025

Light Chain Isotype and Antibody-Specificity Impact on Virus Neutralization.

Lin Sun, Roman Palt, Georg Schütz, Esther Föderl-Höbenreich, Laura Brod, Antonia Hermle, Anja Lux, Herta Steinkellner, Somanath Kallolimath

Abstract read
In one paragraph

Article in Antibodies (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lin SunDepartment of Biotechnology and Food Sciences, Institute of Plant Biotechnology and Cell Biology, BOKU University, Muthgasse 18, 1190 Vienna, Austria.
Roman PaltDepartment of Biotechnology and Food Sciences, Institute of Plant Biotechnology and Cell Biology, BOKU University, Muthgasse 18, 1190 Vienna, Austria.ORCID 0000-0001-9846-5153
Georg SchützCore Facility Biomolecular & Cellular Analysis, BOKU University, 1190 Vienna, Austria.ORCID 0000-0002-3493-6822
Esther Föderl-HöbenreichDiagnostic and Research Institute of Pathology, Medical University of Graz, 8010 Graz, Austria.ORCID 0000-0003-2066-1036
Laura BrodDepartment of Biotechnology and Food Sciences, Institute of Plant Biotechnology and Cell Biology, BOKU University, Muthgasse 18, 1190 Vienna, Austria.
Antonia HermleDivision of Genetics, Department of Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erwin-Rommel-Str. 3, 91058 Erlangen, Germany.
Anja LuxDivision of Genetics, Department of Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erwin-Rommel-Str. 3, 91058 Erlangen, Germany.ORCID 0000-0001-9475-2147
Herta SteinkellnerDepartment of Biotechnology and Food Sciences, Institute of Plant Biotechnology and Cell Biology, BOKU University, Muthgasse 18, 1190 Vienna, Austria.ORCID 0000-0003-4823-1505
Somanath KallolimathDepartment of Biotechnology and Food Sciences, Institute of Plant Biotechnology and Cell Biology, BOKU University, Muthgasse 18, 1190 Vienna, Austria.ORCID 0000-0001-5364-5919

Funding

Austrian Science Fund grant DOI: 10.55776/P35978Austrian Science Fund grant DOI: 10.55776/P37211Austrian Science Fund grant DOI:10.55776/TAI7170424Deutsche Forschungsgemeinschaft grant 401821119/GRK 2504, project C7German Federal Ministry of Education and Science Netzwerk Universitaetsmedizin project "COVIM"
6 · The paper itself

Abstract

Therapeutic antibodies with lambda light chains (λ-Abs) are underrepresented compared to kappa light chains (κ-Abs). Here, we evaluated two SARS-CoV-2-specific monoclonal antibodies (mAbs) that exhibit high (P5C3) and low (H4) antigen binding as κ and λ variants. mAbs expressed in glycoengineered

Indexed as

Fcγ-receptor bindingkappa–lambda light chainmonoclonal antibodiesSARS-CoV-2stabilityvirus neutralization

Identifiers

PMID40558104
PMCPMC12189767

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.