ArticleJournal of medical virology2025
Human Herpesvirus 8 in Solid Organ Transplant Donors and Recipients: Need for Screening? A Dutch Seroprevalence Pilot Study.
Article in Journal of medical virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- HHV-8 Infection in Solid-Organ Transplant-Pathogenesis, Epidemiology, Clinical Manifestations and Management.Reviews in medical virology · 2026Review
- Review
- HHV-8/KSHV in Solid Organ Transplantation: Current Gaps of Knowledge and Future Directions.Transplant infectious disease : an official journal of the Transplantation SocietyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Human Herpesvirus 8 (HHV8) also called Kaposi's Sarcoma-associated herpesvirus (KSHV) is endemic worldwide. It is particularly pathogenic in immunocompromised patients. HHV8 related disease is a rare but dreaded complication in Solid Organ Transplant (SOT) recipients. Particularly donor-derived HHV8 infections can be life threatening and have a high mortality rate. Early recognition is crucial and therefore screening of the highest risk SOT patients could lead to better outcomes. We conducted a pilot study on the seroprevalence of HHV8 in our donor and recipient populations, to calculate the risk for HHV-8 related infections and to evaluate our current screening strategy. A total of 144 donors and 145 recipients were tested with the Indirect fluorescence assay for HHV8 Lytic IgG antibody. Seroprevalence in donors was 2.8% and 10.3% in recipients. This gives a 2.5% chance of donor positive/recipient negative (D+R-) combination, of whom a minority will develop symptomatic disease. Based on this data screening does not seem to be warranted in our center. Further multicenter studies are necessary to gain better insight in risk for symptomatic HHV8 infection in our SOT patients.
trial registrationUMCG Research Register PaNaMa.
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