Evidence map›Paper›PMID 40558048›Full record

ArticlemBio2025

Vitamin C potentiates the killing of

Catherine Vilchèze, Saranathan Rajagopalan, Raja Sab Kalluru, Niaz Banaei, William R Jacobs

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Metabolic perturbation reduces antibiotic tolerance inMicrobiology (Reading, England) · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Catherine VilchèzeDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0001-5960-6670
Saranathan RajagopalanDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Raja Sab KalluruDepartment of Pathology, Stanford University School of Medicine, Stanford, California, USA.
Niaz BanaeiDepartment of Pathology, Stanford University School of Medicine, Stanford, California, USA.
William R JacobsDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0003-3321-3080

Funding

Molecular Genetic Analysis of Mycobacterium TuberculosisR37AI026170 · NIAID · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI WILLIAM Robert JACOBS · 2004 to 2026
$7.7M
MOLECULAR GENETIC ANALYSIS OF MYCOBACTERIUM TUBERCULOSISR01AI026170 · NIAID · YESHIVA UNIVERSITY · PI JACOBS, WILLIAM ROBERT · 1989 to 2022
$7.1M
National Institute of Allergy and Infectious Diseases AI026170NIAID NIH HHS R01 AI026170NIAID NIH HHS R37 AI026170
6 · The paper itself

Abstract

Tuberculosis (TB), a disease caused by the bacterium IMPORTANCE: Tuberculosis (TB) remains a major global health problem, especially as drug-resistant forms become more common and harder to treat. Bedaquiline is one of the most important new drugs for treating these resistant infections, but resistance to bedaquiline is also starting to appear. This study found that the combination of vitamin C and bedaquiline sterilizes

Indexed as

Antitubercular AgentsAscorbic AcidDiarylquinolinesMycobacterium tuberculosisTuberculosis, Multidrug-ResistantCopperDrug Resistance, Multiple, BacterialDrug SynergismDrug Therapy, CombinationGene Expression Regulation, BacterialHomeostasisHumansMetabolic Networks and PathwaysMicrobial Sensitivity TestsMicrobial ViabilityPrimary Cell CultureAntitubercular AgentsAscorbic AcidbedaquilineCopperDiarylquinolinesReactive Oxygen Speciesantibioticsbedaquilinegene expressionmetabolismpersistencesterilizationtuberculosis

Identifiers

PMID40558048
PMCPMC12345178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.