Evidence map›Paper›PMID 40557850›Full record

ArticleChembiochem : a European journal of chemical biology2025

Boosting Antibiotic Efficacy of Azole Drugs against Methicillin-Resistant Staphylococcus Aureus by Coordination to Rhenium Carbonyl Complexes.

Kevin Schindler, Gozde Demirci, Bettina Tran, Sara Nasiri Sovari, Youri Cortat, Nicolas F Rosa De Sousa, Carola Velti, Baptiste Chapuis, Aurélien Crochet, Aleksandar Pavic and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kevin SchindlerDepartment of Chemistry, Fribourg University, Chemin Du Musée 9, 1700, Fribourg, Switzerland.ORCID https://orcid.org/0000-0001-5487-2283
Gozde DemirciDepartment of Chemistry, Fribourg University, Chemin Du Musée 9, 1700, Fribourg, Switzerland.ORCID https://orcid.org/0000-0003-4952-7981
Bettina TranDepartment of Chemistry, Fribourg University, Chemin Du Musée 9, 1700, Fribourg, Switzerland.
Sara Nasiri SovariDepartment of Chemistry, Fribourg University, Chemin Du Musée 9, 1700, Fribourg, Switzerland.
Youri CortatDepartment of Chemistry, Fribourg University, Chemin Du Musée 9, 1700, Fribourg, Switzerland.ORCID https://orcid.org/0009-0001-9414-2098
Nicolas F Rosa De SousaDepartment of Chemistry, Fribourg University, Chemin Du Musée 9, 1700, Fribourg, Switzerland.
Carola VeltiDepartment of Chemistry, Fribourg University, Chemin Du Musée 9, 1700, Fribourg, Switzerland.
Baptiste ChapuisDepartment of Chemistry, Fribourg University, Chemin Du Musée 9, 1700, Fribourg, Switzerland.
Aurélien CrochetDepartment of Chemistry, Fribourg University, Chemin Du Musée 9, 1700, Fribourg, Switzerland.ORCID https://orcid.org/0000-0002-4763-2764
Aleksandar PavicInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042, Belgrade, Serbia.ORCID https://orcid.org/0000-0003-3233-1341
Jelena DjurisDepartment of Pharmaceutical Technology and Cosmetology, University of Belgrade, Vojvode Stepe 450, 11221, Belgrade, Serbia.ORCID https://orcid.org/0000-0002-1833-6704
Stefan SalentinigDepartment of Chemistry, Fribourg University, Chemin Du Musée 9, 1700, Fribourg, Switzerland.
Fabio ZobiDepartment of Chemistry, Fribourg University, Chemin Du Musée 9, 1700, Fribourg, Switzerland.ORCID https://orcid.org/0000-0002-9077-7184

Funding

Faculté des Sciences et de Médecine, Université de Fribourg FC-23-901Ministry of Science, Technological Development, and Innovation of the Republic of Serbia 451-03-66/2024-03/200042, 451-03-66/2024-03/ 200161Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 200021_196967, IZBRZ2_186251
6 · The paper itself

Abstract

Herein, a library of rhenium di- and tricarbonyl complexes featuring various antimicrobial azoles as monodentate ligands is synthesized and characterized. Their antimicrobial activity is evaluated against both methicillin-sensitive (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA), and selected compounds are also assessed for cytotoxicity, yielding promising therapeutic indices. Notably, the complexation of antifungal azoles to the rhenium core enhances antimicrobial efficacy, with a compound exhibiting up to a 32-fold improvement in minimum inhibitory concentration (MIC) values relative to the parent azole. Structure-activity relationships indicate that cationic fac-[Re(CO)

Indexed as

Anti-Bacterial AgentsAzolesCoordination ComplexesMethicillin-Resistant Staphylococcus aureusRheniumHumansMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipAnti-Bacterial AgentsAzolesCoordination ComplexesRheniumantifungal azolesantimicrobialcarbonylrheniumS. aureus

Identifiers

PMID40557850
PMCPMC12432483

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.