ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
A Two-Protein Chemoreceptor Complex Regulates Oxygen Thresholds in Bacterial Magneto-Aerotaxis.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- A cumate-inducible promoter system for tuned gene expression and magnetosome overproduction in magnetotactic bacteria.Applied microbiology and biotechnology · 2026Article
- Diversity of Pharmaceuticals Enhances Antibiotic Resistance in the Invertebrate Gut via Biofilm-Mediated Mechanisms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Directional matching of swimming polarity provides a competitive advantage during bacterial magneto-aerotaxis.BMC microbiology · 2026Article
- Review
- A Two-Protein Chemoreceptor Complex Regulates Oxygen Thresholds in Bacterial Magneto-Aerotaxis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Bacteria in changing environments rely on motility and sensory mechanisms to locate optimal conditions. This process depends on specialized chemoreceptors to sense environmental stimuli. Exceptionally high numbers of chemoreceptor genes are present in magnetotactic bacteria (MTB), which combine magnetic alignment via intracellular magnetic nanoparticles (magnetosomes) and oxygen sensing for a unique navigation strategy toward low-oxygen zones, called magneto-aerotaxis. However, chemoreceptors for aerotaxis in MTB have not been experimentally identified. This study examines chemoreceptors in the model MTB Magnetospirillum gryphiswaldense. Gene deletion analysis shows that M. gryphiswaldense relies on a complex and partly redundant set of chemoreceptors to sense oxygen. Within this diverse repertoire of chemoreceptors, a receptor formed by two interacting proteins is identified that plays a key role in aerotaxis. Interaction assays and microscopy confirm that both proteins interact within polar-lateral regions in the cell. Moreover, genetic, biochemical, and motility experiments demonstrate that the chemoreceptor complex promotes a cellular response away from oxygen via the redox cofactor flavin adenine dinucleotide (FAD), independent of magnetic fields. These findings provide first insights into how MTB control oxygen sensing at the molecular level, shedding light on the mechanisms underlying bacterial navigation and highly complex chemosensory systems.
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