Trial reportJournal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]2025
Influence of Different Protocols on In-Office Bleaching: Whiteness Difference and Hydrogen Peroxide Penetration.
Trial report in Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.], 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Influence of Different Protocols on In-Office Bleaching: Whiteness Difference and Hydrogen Peroxide Penetration.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2025Trial
- Evaluation of tooth sensitivity and whitening effects of tooth whitening agents containing calcium, hydroxyapatite and fluoride.Odontology · 2026Article
- Effects of Overnight Whitening Pens on Hydrogen Peroxide Penetration, Color Change, and Enamel Surface Properties.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026Article
- Synthesis, characterization and evaluation of novel bleaching gels containing bioactive glass and nano-hydroxyapatite on hydrogen peroxide diffusion, bleaching efficacy and enamel protection.Clinical oral investigations · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectivesTo evaluate whiteness difference (WI MATERIALS AND
methodsA total of 154 human premolars were randomly assigned to 11 groups (n = 14). The groups were divided into: Pola Office+ and Pola Rapid (SDI), and the following protocols: three applications of 8 min (3 × 8), two applications of 8 min (2 × 8), one application of 8 min (1 × 8), one application of 16 min (1 × 16), and one application of 24 min (1 × 24). These protocols were selected based on manufacturer recommendations and the aim of exploring simplified and alternative approaches applicable to clinical practice. One group served as a negative control. WI
resultsSignificant WI
conclusionAmong the evaluated protocols, the 2 × 8-min and 1 × 24-min applications provided the best balance between achieving significant whitening and minimizing hydrogen peroxide penetration into the pulp chamber, making them effective and safer alternatives for in-office bleaching. CLINICAL RELEVANCE: Shorter application times (2 × 8 min) or a single prolonged application (1 × 24 min) provide effective alternatives for achieving excellent whitening index results. These protocols reduce hydrogen peroxide penetration into the pulp chamber while also shortening the overall procedure time, enhancing both safety and efficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.