ArticleAdvanced materials (Deerfield Beach, Fla.)2025
Ancestral Protein-Based Lighting.
Article in Advanced materials (Deerfield Beach, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Integrating Vibrio natriegens for Photon Manipulation in Living Lighting Devices.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Ancestral Protein-Based Lighting.Advanced materials (Deerfield Beach, Fla.) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Protein-optoelectronics is a paradigm toward eco-designed and sustainable technologies. The challenge is, however, how to preserve the native activity of proteins upon device fabrication/operation in non-native environments (solvents, organic/inorganic interfaces, and working temperatures/irradiations). Herein, a new vision to identify and design ancestral-like fluorescent proteins (FPs) is proposed. Using ancestral sequence reconstruction (ASR) out of a large dataset (221) of the best modern FPs suitable for photon down-conversion in bio-hybrid light-emitting diodes (Bio-HLEDs) a historical-genetic reconstruction (family tree) was obtained, identifying a possible common ancestral FP. This computationally designed protein is produced in bacteria, featuring outstanding photoluminescence quantum yields in solution (e.g., 90%/80% for green-/red-emitting forms) and a strong tendency to agglomerate in polymer coatings. This resulted in red-emitting Bio-HLEDs that outperformed the reference with ≈2-fold enhanced stabilities. The resplendent green-/red-emission of ancestral-like FP itself and its respective devices led us to coin this new protein as QuetzalFP. Overall, it is set in ASR as an effective concept to reshape protein-optoelectronics allowing us to identify i) many interesting ancestral FPs for lighting and ii) QuetzalFP as stepping-stone platform for protein engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.