Evidence map›Paper›PMID 40557412›Full record

ArticleJournal of current ophthalmology

Corneal Endothelial Cell Changes Associated with Multiple Intravitreal Injections.

Mariaelena Malvasi, Pietro Mangiantini, Floriana Testa, Edoardo Trovato Battagliola, Mattia D'Andrea, Guglielmo Minozzi, Paolo Turchetti, Elena Pacella

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of current ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mariaelena MalvasiDepartment of Sense Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome, Italy.
Pietro MangiantiniDepartment of Sense Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome, Italy.
Floriana TestaDepartment of Sense Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome, Italy.
Edoardo Trovato BattagliolaDepartment of Sense Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome, Italy.
Mattia D'AndreaDepartment of Sense Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome, Italy.
Guglielmo MinozziDepartment of Sense Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome, Italy.
Paolo TurchettiNational Institute for Health, Migration and Poverty, Rome, Italy.
Elena PacellaDepartment of Sense Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To explore the changes in the corneal endothelium in patients who receive multiple anti-vascular endothelial growth factor (anti-VEGF) or steroid injections for posterior segment pathology. Methods: This cross-sectional study recruits subjects treated with intravitreal anti-VEGF or sustained-release dexamethasone for macular edema due to retinal vein occlusion. Corneal endothelium and corneal thickness were measured in the treated eye using a corneal endothelial microscope. The study variables include age, endothelial cell density (ECD), coefficient of variation (CV) of cell size, percentage of hexagonality (HEX%), and intraocular pressure (IOP) change 30 min after injection. These variables were analyzed using multiple linear regression analysis. Results: A total of 108 diseased eyes were treated with a variable number (from 4 to 28) of intravitreal injections between January 2020 and December 2023. The mean total number of intravitreal injections was 12.8/eye. Multiple linear regression analysis showed an inverse relationship between ECD and age ( Conclusion: A greater number of intravitreal injections is associated with a lower ECD, lower HEX, and higher CV in the treated eyes.

Indexed as

Anti-vascular endothelial growth factorCorneal endotheliumDexamethasone implantEndothelial cell countIntravitreal injections

Identifiers

PMID40557412
PMCPMC12184871

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.