Evidence map›Paper›PMID 40557352›Full record

ArticleAnnals of surgery open : perspectives of surgical history, education, and clinical approaches2025

Association Between Opioid Use Disorder and Healthcare Spending and Utilization in Emergency Surgical Patients: A Retrospective Analysis Using Commercial Claims.

Anjali A Dixit, Pooja A Lagisetty, Michelle C Odden, Mark C Bicket, Keith R Humphreys, Sean C Mackey, Eric C Sun

Abstract read
In one paragraph

Article in Annals of surgery open : perspectives of surgical history, education, and clinical approaches, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anjali A DixitFrom the Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA.
Pooja A LagisettyDepartment of Medicine, University of Michigan School of Medicine, Ann Arbor, MI.
Michelle C OddenDepartment of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA.
Mark C BicketOverdose Prevention Engagement Network, Institute for Healthcare Innovation and Policy, University of Michigan School of Medicine, Ann Arbor, MI.
Keith R HumphreysDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine; Stanford, CA.
Sean C MackeyFrom the Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA.
Eric C SunFrom the Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA.

Funding

Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0M
Research in Anesthesia Training Program (ReAP)T32GM089626 · NIGMS · STANFORD UNIVERSITY · PI Vivianne L Tawfik · 2010 to 2026
$5.2M
The Impact of Surgery on Outcomes for Patients taking Medications for Opioid Use DisorderR01DA057943 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mark Bicket, Thuy Dieu Nguyen · 2023 to 2026
$2.7M
The Use of Novel Linked Databasesto Reduce Postoperative Opioid Use Among Patients Undergoing Inpatient SurgeryR61DA059168 · NIDA · STANFORD UNIVERSITY · PI COLQUHOUN, DOUGLAS ALASTAIR, SUN, ERIC · 2023 to 2023
$1.1M
The Impact of Discontinuing Medications for Opioid Use Disorder After Surgery: Evaluating Predictors and Outcomes to Guide Perioperative CareK08DA060977 · NIDA · STANFORD UNIVERSITY · PI Anjali Ashish Dixit · 2025 to 2026
$384k
NCATS NIH HHS UL1 TR003142NIDA NIH HHS K08 DA060977NIDA NIH HHS R01 DA057943NIDA NIH HHS R61 DA059168NIGMS NIH HHS T32 GM089626
6 · The paper itself

Abstract

Objective: To estimate the association between opioid use disorder (OUD) and healthcare spending and utilization in emergency surgical patients, and to evaluate whether the use of opioid agonist treatment (OAT) modifies this relationship. Background: Surgical patients with OUD are susceptible to challenging postoperative pain management and relapse. Their healthcare spending and utilization estimates may justify perioperative system optimization efforts. Methods: We identified 142,726 patients who underwent 1 of 14 surgeries between January 1, 2016 and December 31, 2021. We then estimated the association between OUD and primary outcomes (spending during the surgical admission and in the 1-90 days postdischarge) and secondary outcomes (measures of healthcare utilization). We further evaluated whether the use of OAT modified the relationship between OUD and outcomes. Results: Those with Conclusions: Emergency surgical patients with OUD had higher healthcare spending and utilization following discharge compared to those without OUD, implying an elevated risk of complications. Optimizing preoperative use of OAT may facilitate perioperative optimization and cost savings.

Identifiers

PMID40557352
PMCPMC12185090

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.