Evidence map›Paper›PMID 40557278›Full record

ArticleFrontiers in pain research (Lausanne, Switzerland)2025

Case Report: Lateral C1-C2 puncture for intrathecal baclofen therapy: an alternative effective and safe approach after spinal cord injury.

Rayan Fawaz, Hayat Belaid, Baptiste Eklu, Jean Baptiste Thiebaut, Manon Duraffourg

Abstract readCase Reports
In one paragraph

Article in Frontiers in pain research (Lausanne, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rayan FawazDepartment of Neurosurgery, Hôpital de la Fondation Adolphe de Rothschild, Paris, Cedex, France.
Hayat BelaidDepartment of Neurosurgery, Hôpital de la Fondation Adolphe de Rothschild, Paris, Cedex, France.
Baptiste EkluService de Médecine Physique et de Réadaptation, Hôpital Henry Gabrielle, Hospices Civils de Lyon, Lyon, France.
Jean Baptiste ThiebautDepartment of Neurosurgery, Hôpital de la Fondation Adolphe de Rothschild, Paris, Cedex, France.
Manon DuraffourgUnité de Neuromodulation Polyvalente, Service de Neurochirurgie Fonctionnelle, Hôpital Neurologique et Neurochirurgical Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spasticity is a neurological disorder that disrupts the regulation of muscle tone following an injury to the central nervous system, such as spinal cord injury. Baclofen is the most effective medication for treating spasticity and can be delivered via a pump connected to an intrathecal catheter. The catheter is typically inserted via a lumbar punction and advanced up to the level corresponding to the disturbing spasticity. But this may not be possible, especially when cervical level is involved. We present the case of a patient with severe spasticity after a traumatic cervical spinal cord injury who successfully underwent a lateral C1-2 puncture for placement of a retrograde catheter to the C4 level, after an unsuccessful attempt at catheter placement via a lumbar puncture. The patient experienced a significant reduction in spasticity with no reported worsening during the 8 months follow-up period. The catheter placement via a lateral C1-2 puncture guided by innovative imagery with 3D reconstruction, may serve as an effective and safe alternative to deliver baclofen at the cervical level. Relevance of cervical ITB is discussed and issues involved are considered. The mechanism of action of ITB at cervical level, which is far from fully clarified, is crucial to reach the best clinical outcome and avoid si de effects and complications. Few clinical cases were published; hence the importance to present this case.

Indexed as

C1–C2 puncturecervical intrathecal baclofenintrathecalpumpspinal cord injury

Identifiers

PMID40557278
PMCPMC12185545

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.