Evidence map›Paper›PMID 40557248›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2025

Comparative electrophysiological study of neuroactive steroid-induced hypnosis in mice: sex and drug-specific differences.

Abigail Martin, Ian Coulter, Reginald Cox, Douglas F Covey, Slobodan M Todorovic, Tamara Timic Stamenic

Abstract readComparative Study
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. 2024 international conference on neuroprotective agents conference proceedings.Experimental biology and medicine (Maywood, N.J.) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Abigail MartinDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Ian CoulterDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Reginald CoxDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Douglas F CoveyDepartment of Developmental Biology, Washington University School of Medicine, Saint Louis, MO, United States.
Slobodan M TodorovicDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Tamara Timic StamenicDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

Funding

The role of T-type calcium channels in the morphine effects in the nonspecific thalamusK01DA055258 · NIDA · UNIVERSITY OF COLORADO DENVER · PI Tamara Timic Stamenic · 2022 to 2026
$889k
NIDA NIH HHS K01 DA055258
6 · The paper itself

Abstract

Since the discovery of their anesthetic effects, some neuroactive steroids have been used as general anesthetics. However, their effects on thalamocortical oscillations and potential sex differences that are associated with their hypnotic/sedative effects are not well studied. Here, we investigated spectral characteristics and sex differences in hypnotic effect of two common neuroactive steroids: Allopregnanolone (AlloP) and its synthetic analog Alphaxalone (Alpx) in wild type mice using behavioral testing (loss of righting reflex - LORR) and

Indexed as

HypnosisHypnotics and SedativesPregnanedionesPregnanoloneAnimalsElectroencephalographyElectrophysiological PhenomenaFemaleMaleMiceMice, Inbred C57BLReflex, RightingSex CharacteristicsalphaxaloneHypnotics and SedativesPregnanedionesPregnanoloneelectroencephalogramhypnosisneuroactive steroidsphase locking valuesex-differences

Identifiers

PMID40557248
PMCPMC12185358

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.