ArticleMediterranean journal of rheumatology2025
A Randomised Double-Blind Placebo-Controlled Clinical Trial of Fish Oil (Omega-3) in Sjögren's Syndrome Patients in Erbil-Iraq.
Article in Mediterranean journal of rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05005806 (Randomised Double-blind Placebo-controlled Clinical Trial of Fish Oil), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomised Double-blind Placebo-controlled Clinical Trial of Fish Oil (Omega 3 ) in Sjögren's Syndrome Patients
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Sjögren's syndrome (SS) is an autoimmune condition that primarily targets glands that are exocrine. Fish oil supplements have been explored for their potential to decrease pain, reduce stiffness in the morning, and improve joint tenderness among rheumatic disease patients. Aim of study: to assess effectiveness of omega-3 fatty acids for controlling symptoms of dry eye and dry mouth in individuals diagnosed with Sjögren's syndrome. Patients and Methods: A randomised, double-blind, placebo-controlled clinical trial was conducted over a two-month period. clinical trial registration (ID: NCT05005806). Dry eye symptoms were assessed using a six-point scoring system (0-3). Dry mouth symptoms were evaluated using a visual analogue scale (VAS). Secondary outcomes included Schirmer's test and sialometry test. Results: The analysis included a total of 104 people with Sjögren's syndrome. The mean score of dry eye symptoms was significantly lower in omega-3 Group (4.85 ± 4.10 SD, 95% CI: 3.75, 5.95) compared to the placebo group (8.27 ± 5.72 SD, 95% CI: 6.60, 9.93; P value = 0.001). Schirmers test after treatment, improved significantly to normal values in both groups which was slightly better among the omega-3 group. Sialometry tests indicated normalisation of salivary flow rate in the omega-3 group (2.07 ± 1.67 SD, 95% CI: 1.63, 2.52) (P value = 0.053). Conclusion: Omega-3 fatty acids effectively improved dry mouth and dry eye symptoms. Furthermore, this led to significant normalisation of salivary flow rate. While Schirmer's test results improved in both groups, the differences between the omega-3 and placebo groups were insignificant.
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