ArticleOpen veterinary journal2025
Characterization of the effect of graded doses of dexamethasone administration on the functional system and maternal prenatal Wistar rat (
Article in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Impact of dexamethasone on cortisol and luteinizing hormone levels in dairy goats with subclinical mastitis in Siliragung District, Banyuwangi.Open veterinary journal · 2025Article
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Authors and funding
13 authors.
Funding
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Abstract
Background: Misuse of dexamethasone as a synthetic glucocorticoid anti-inflammation drug is prevalent because of its affordability and therapeutic benefits, despite frequent disregard for proper usage guidelines. Aim: This study investigated the effects of dexamethasone administration during the second trimester of pregnancy, which is the success or failure factor of final stage fetal development on progesterone, luteinizing hormone (LH), and endometrial thickness in Wistar rats. Methods: The study involved 120 pregnant female Wistar rats divided into four treatment groups as follows: C as the control without injection, T1 receiving dexamethasone doses of 0.36 mg/day, T2 receiving dexamethasone doses of 0.72 mg/day, and T3 receiving dexamethasone doses of 0.75 mg/day, which received injection treatment for seven consecutive days (days 8-14 of pregnancy). At the end of the study period, the following parameters were measured: progesterone, LH, and endometrial thickness. Results: Dexamethasone significantly decreased progesterone levels, LH, and endometrial thickness ( Conclusion: Dexamethasone administration during the second trimester caused adverse hormonal imbalances and disrupted endometrial development in pregnant rats. These findings underscore the risks of glucocorticoid misuse during pregnancy. Proper adherence to medical guidelines is crucial for minimizing the detrimental effects on reproductive function and fetal development. This study emphasizes the importance of monitoring and regulating dexamethasone use, particularly in pregnant individuals, to safeguard maternal and fetal health.
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