Evidence map›Paper›PMID 40557080›Full record

ArticleOpen veterinary journal2025

Mechanism of recombinant 1,3-β-glucanase as antibiofilm to prevent antimicrobial resistance in antifungal therapy for vulvovaginitis candidiasis.

Masfufatun Masfufatun, Afaf Baktir, Rini Purbowati

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Masfufatun MasfufatunDepartment of Biochemistry, Faculty of Medicine, Universitas Wijaya Kusuma Surabaya, Surabaya, Indonesia.
Afaf BaktirDepartment of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
Rini PurbowatiDepartment of Biomedical and Biomolecular Research, Faculty of Medicine, Universitas Wijaya Kusuma Surabaya, Surabaya, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Aim: This study aimed to study the mechanism of recombinant β-1,3-glucanase activity as an antibiofilm agent to increase the effectiveness of antifungals in treating vulvovaginitis candidiasis (VVC). Methods: Recombinant β-1,3-glucanase was produced using recombinant DNA technology and tested for its antibiofilm activity against Results: The results showed that recombinant β-1,3-glucanase affected all stages of Conclusion: These findings indicate the great potential of β-1,3-glucanase to be applied as an antifungal concomitant agent for overcoming antimicrobial resistance in biofilm infections such as VVC. Further studies are needed to evaluate the effectiveness of the drug in

Indexed as

Antifungal AgentsBiofilmsCandida albicansCandidiasis, VulvovaginalDrug Resistance, FungalGlucan 1,3-beta-GlucosidaseFluconazoleRecombinant ProteinsAntifungal AgentsFluconazoleGlucan 1,3-beta-GlucosidaseRecombinant ProteinsAntimicrobial resistanceC. albicans biofilmFluconazoleRecombinant β-1,3-glucanaseVulvovaginitis candidiasis

Identifiers

PMID40557080
PMCPMC12184442

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.