SynthesisOpen veterinary journal2025
Survival and functional outcomes following surgical repair of pathological fractures in dogs: A meta-analysis.
Synthesis in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Background: Pathological fractures result from abnormal bone remodeling caused by local bone lesions, such as malignant tumors, compromising bone strength. Tumor-derived factors disrupt the balance between bone resorption and formation, leading to osteolytic and osteosclerotic lesions that weaken bone integrity. While surgical treatments, including limb amputation and limb-sparing surgery, are commonly used, the therapeutic efficacy of fracture repair remains unclear due to limited evidence. Aim: This study characterized pathological fractures and evaluated survival time and functional prognoses following surgical repair in dogs. The goal was to provide robust evidence to inform clinical decision-making and improve treatment outcomes. Methods: A systematic review and meta-analysis were conducted following a PRISMA-compliant approach. MEDLINE (PubMed) and Google Scholar were used to search for relevant studies published from database inception to March 1, 2025. Data from past reports were integrated with cases from our institution, comprising 70 dogs with pathological fractures. Survival and prognosis were analyzed using the Kaplan-Meier method, and outcomes between adjuvant chemotherapy were compared using the log-rank test. Results: Osteosarcoma was the most common cause of pathological fractures ( Conclusion: Surgical stabilization of pathological fractures resulting from osteosarcoma should be considered a palliative treatment option for cases in which amputation is declined by the owner or in dogs with advanced disease, including metastatic lesions. With appropriate patient selection, this approach may represent a viable third-line treatment following limb-sparing surgery and amputation.
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