ArticleOpen veterinary journal2025
Analysis of ovarian morphometry and age-related T Lymphocyte localization in adult (
Article in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Dwarf hamsters are extensively used as models in reproductive disorders studies, reproductive endocrinology, embryo transplantation, and Aim: This study aimed to explore the morphological and morphometric development of the ovary with T lymphocyte distribution at different ages using immunohistochemical cluster of differentiation 40 (CD40) expression. Methods: Fifteen dwarf hamster ( Results: At 2 weeks of age, the observations showed symmetric development of the ovaries, with no significant differences in dimensions and weight. Histologically, the ovaries displayed early follicle development with sparse T lymphocytes. At 4 weeks, follicular size asymmetry emerged with the presence of corpus luteum and increased T lymphocyte counts. By 8 weeks, the ovaries exhibited more developed ovarian follicles, larger corpus luteum, and a further increase in T-lymphocyte density. Conclusion: This investigation sheds light on the development of the ovary in dwarf hamsters, an understudied model with a short maturity age. These findings provide a promising understanding of ovarian morphological development and the diagnosis of various infertility developmental disorders.
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