ArticleJournal of inflammation research2025
Probiotic Bifico Ameliorates Depression- and Anxiety-Like Behaviors Induced by Estrogen Deficiency via NLRP3 Inflammasome Inhibition.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- Article
- Regulatory role and mechanism of the probiotics on monosodium urate crystal-induced gout inflammation.Clinical rheumatology · 2026Article
- The Combination ofNutrients · 2026Article
- Establishment and investigation of a surgical model of hypothyroidism in Wistar rats.PloS one · 2026Article
- Gut microbiota dysbiosis induces neuroinflammation in major depressive disorders: mechanisms targeting the gut-brain axis.Frontiers in psychiatry · 2025Review
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8 authors.
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Abstract
Purpose: Dysregulation of the microbiota-gut-brain (MGB) axis and activation of the NOD-like receptor protein 3 (NLRP3) inflammasome are implicated in estrogen deficiency induced depression and anxiety disorders. This study aims to investigate the effects of the probiotic Bifico on neuroinflammation and behaviors in ovariectomized (OVX) rats. Methods: After OVX rats were treated with Bifico for 6 weeks, depression- and anxiety-like behaviors were evaluated using the sucrose preference test, forced swimming test, open field test and elevated plus maze. Furthermore, 16S rRNA sequencing was used to analyze changes in gut microbiota. Hematoxylin-eosin (HE) staining was used to observe the changes in tissue structure (intestinal tissue and hippocampus). Enzyme-linked immunosorbent assay (ELISA) was used to detect inflammatory factors. Western blot was used to detect tissue protein levels. Results: The treatment of Bifico for 6 weeks can ameliorate depression- and anxiety-like behaviors induced by estrogen deficiency. In addition, Bifico increased the abundance of gut microbiota, especially Conclusion: Our findings suggest that probiotics ameliorate the depression- and anxiety-like behaviors in OVX rats by alleviating gut microbiota dysbiosis and reduce gut inflammation, thereby dampening neuroinflammation via inhibition of the NLRP3 inflammasome signaling pathway in the hippocampus. Therefore, NLRP3 inflammasome activation mediated by the MGB axis may be a potential therapeutic target for estrogen deficiency-induced affective disorders.
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