Evidence map›Paper›PMID 40557039›Full record

ArticleFrontiers in medicine2025

Histopathological spectrum of common aldosterone-driver gene mutations in aldosterone-producing adenomas.

Fatin Athirah Pauzi, Muaatamarulain Mustangin, Geok Chin Tan, Ales Ryska, Jiri Ceral, Miroslav Solar, Elena Aisha Azizan

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Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Fatin Athirah PauziFaculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia.
Muaatamarulain MustanginFaculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia.
Geok Chin TanFaculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia.
Ales RyskaCharles University and University Hospital Hradec Kralove, Hradec Kralove, Czechia.
Jiri CeralCharles University and University Hospital Hradec Kralove, Hradec Kralove, Czechia.
Miroslav Solar *Charles University and University Hospital Hradec Kralove, Hradec Kralove, Czechia.
Elena Aisha Azizan *Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Past studies on common mutant aldosterone-producing adenomas (APAs) had found genotype-phenotype correlations associated with histological appearance. Most of these studies did not perform CYP11B2-guided sequencing of APAs or sequencing for all the currently known aldosterone-driver genes. Hence, misinterpretation of the genotype-phenotype correlations could have occurred. Herein, we aimed to identify the genotype-phenotype correlations associated with the histopathology of the different mutant APAs utilizing CYP11B2-guided sequencing. A total of 33 APAs with confirmed aldosterone-driver mutation (17

Indexed as

aldosterone-driver mutationsaldosterone-producing adenomasCYP11B2-guided sequencinggenotype–phenotype correlationsimmunohistochemistry analysis

Identifiers

PMID40557039
PMCPMC12185499

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