ArticleFrontiers in public health2025
Prevalence and antibiotic resistance of pathogens isolated from neurosurgical patients with postoperative central nervous system infections in a tertiary hospital in North China.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Rifampin monotherapy for multidrug-resistantFrontiers in medicine · 2025Article
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6 authors.
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Abstract
Background: Postoperative central nervous system infection (PCNSI) is a serious complication following neurosurgery. Effective clinical management of PCNSI requires prompt antibiotic administration based on the identification of the causative pathogens and antibiotic resistance. This study aimed to investigate the causative pathogens of PCNSI and their antibiotic resistance profiles, which could help clinicians initiate appropriate empirical antibiotic therapy. Methods: The distribution and antimicrobial resistance of pathogens in patients with PCNSI from January 2014 to December 2023 were analyzed retrospectively. Cerebrospinal fluid samples were aseptically collected and subjected to standard microbiological methods for bacterial isolation and identification. Antibiotic sensitivity testing was performed via the Kirby-Bauer disk diffusion agar method. Results: A total of 396 patients were diagnosed with PCNSI, and 385 pathogens were identified from these patients. The percentages of Gram-positive bacteria, Gram-negative bacteria, and fungi were 56.10, 41.30, and 2.60%, respectively. The predominant pathogens among the Gram-positive bacteria were coagulase-negative staphylococci (29.09%), whereas Conclusion: Gram-positive bacteria, especially coagulase-negative staphylococci, were the predominant pathogens causing PCNSI. Furthermore, several Gram-negative species, especially
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