ArticleFrontiers in endocrinology2025
Effects of metabolic and organ function factors on the efficacy of radioactive iodine therapy for hyperthyroidism.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- From data to decision: an interpretable machine learning model for optimizing RAI therapy in Graves' hyperthyroidism.Frontiers in endocrinology · 2025Article
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5 authors.
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Abstract
Introduction: Recent studies suggest that metabolic and organ function indicators could influence radioactive iodine treatment (RAIT) efficacy in hyperthyroid patients, but their relationships with thyroid function remain unclear. Objective: This study aims to explore the impact of these markers on RAIT efficacy and thyroid function. Method: A total of 135 hyperthyroid patients undergoing RAIT were enrolled, with biomarkers collected at baseline and 1, 3, and 6 months posttreatment. These included thyrotropin receptor antibody (TRAb), free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), urinary iodine concentration (UIC), serum iodine concentration (SIC), 25-hydroxyvitamin D, alanine aminotransferase, aspartate aminotransferase, and serum creatinine (Scr). We mainly focus on the outcomes of the impact of metabolic and organ function markers on RAIT efficacy and their correlation with changes in thyroid function. Results: Logistic regression identified age as a predictor of RAIT efficacy (OR = 0.957, Conclusion: Age was a relative factor influencing RAIT efficacy, while iodine nutritional status exhibited dynamic, time-dependent effects on TRAb and TSH. Elevated Scr promotes reductions in FT3 and FT4 and an increase in TSH.
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