Evidence map›Paper›PMID 40556784›Full record

ReviewACS bio & med chem Au2025

Leveraging the Capsular Polysaccharide Synthesis Pathway in

Cheryl Kang-Rou Wong, Ye-Yu Chun, Tong Su, Lok-To Sham

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in ACS bio & med chem Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cheryl Kang-Rou WongInfectious Diseases Translational Research Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore.
Ye-Yu ChunInfectious Diseases Translational Research Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore.
Tong SuInfectious Diseases Translational Research Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore.
Lok-To ShamInfectious Diseases Translational Research Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore.ORCID https://orcid.org/0000-0001-9047-0310

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Engineering carbohydrates in living cells is one of the overarching goals of biology. In this Perspective, we discuss recent work in response to this challenge. Compared with eukaryotic cells, bacteria are fast-growing and genetically tractable. At the species level, glycans in prokaryotes are highly variable, contrasting with the homogeneity of surface glycans, such as capsular polysaccharides (CPSs), at the strain level. We exploited the conditional essentiality of the CPS synthesis pathway in

Indexed as

capsular polysaccharide synthesisGenetic glycoengineeringglycan synthesisglycoconjugateglycosyltransferaseStreptococcus pneumoniae

Identifiers

PMID40556784
PMCPMC12186847

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.