Evidence map›Paper›PMID 40556703›Full record

ArticleRSC advances2025

Interaction of cardiomyocytes from CCND2-overexpressing human induced pluripotent stem cells with electrically conductive hydrogels.

Michelle Jang, Yura Son, Alejandra Patino-Guerrero, Yamini Singh, Keagan Neff, Mehdi Nikkhah, Wuqiang Zhu

Abstract read
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michelle JangSchool of Biological and Health Systems Engineering, Arizona State University Tempe AZ 85287 USA Mehdi.Nikkhah@asu.edu.
Yura SonDepartment of Cardiovascular Medicine, Physiology and Biomedical Engineering, Center for Regenerative Biotherapeutics, Mayo Clinic Scottsdale AZ 85259 USA Zhu.Wuqiang@mayo.edu.
Alejandra Patino-GuerreroDepartment of Cardiovascular Medicine, Physiology and Biomedical Engineering, Center for Regenerative Biotherapeutics, Mayo Clinic Scottsdale AZ 85259 USA Zhu.Wuqiang@mayo.edu.
Yamini SinghSchool of Biological and Health Systems Engineering, Arizona State University Tempe AZ 85287 USA Mehdi.Nikkhah@asu.edu.
Keagan NeffSchool of Biological and Health Systems Engineering, Arizona State University Tempe AZ 85287 USA Mehdi.Nikkhah@asu.edu.
Mehdi NikkhahSchool of Biological and Health Systems Engineering, Arizona State University Tempe AZ 85287 USA Mehdi.Nikkhah@asu.edu.
Wuqiang ZhuDepartment of Cardiovascular Medicine, Physiology and Biomedical Engineering, Center for Regenerative Biotherapeutics, Mayo Clinic Scottsdale AZ 85259 USA Zhu.Wuqiang@mayo.edu.ORCID https://orcid.org/0000-0001-5217-7789

Funding

Cardiomyocyte Non-autonomous Factors and Cardiac Regeneration in Large MammalsR01HL156855 · NHLBI · MAYO CLINIC ARIZONA · PI Wuqiang Zhu · 2022 to 2026
$3.3M
Strategies to Enhance Engineered Heart Tissue Based Myocardial RepairR01HL162747 · NHLBI · MAYO CLINIC ARIZONA · PI Jingwei Xie, Wuqiang Zhu · 2023 to 2026
$2.9M
Electrically Conductive Stem Cell Derived MicroEngineered Heart Tissue for Regeneration of Injured MyocardiumR01HL172784 · NHLBI · MAYO CLINIC ARIZONA · PI Mehdi Nikkhah, Wuqiang Zhu · 2024 to 2026
$2.0M
Myocardial Repair with a Novel Engineered Cardiac Muscle PatchR01HL142627 · NHLBI · MAYO CLINIC ARIZONA · PI ZHU, WUQIANG · 2019 to 2022
$1.7M
NHLBI NIH HHS R01 HL142627NHLBI NIH HHS R01 HL156855NHLBI NIH HHS R01 HL162747NHLBI NIH HHS R01 HL172784
6 · The paper itself

Abstract

The use of biomaterials has been widely studied as a platform to deliver regenerative cells, such as human induced pluripotent stem cells-derived cardiomyocytes (hiPSC-CMs), into damaged heart tissue. However, these biomaterials often lack the electroconductivity needed for effective heart function. In this study, we developed a gold nanorod-embedded gelatin-methacrylate (GelMA-GNR) hydrogel scaffold seeded with hiPSC-CMs and hiPSC-derived cardiac fibroblasts (hiPSC-CFs). Three experimental groups, pristine GelMA (GelMA), GelMA embedded with 0.5 mg mL

Identifiers

PMID40556703
PMCPMC12186851

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.