ArticleFrontiers in neurology2025
Diagnostic yield of intraoperative frozen sections obtained through robot-assisted stereotactic biopsy of brain lesions.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- The role of intraoperative flow cytometry on intracranial tumor surgery : a scoping review.Neurosurgical review · 2025Article
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8 authors.
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Abstract
Objective: To evaluate the diagnostic yield and diagnostic accuracy of intraoperative frozen sections obtained through robot-assisted stereotactic biopsy of brain lesions. Methods: The medical records of 87 patients who underwent 89 robot-assisted stereotactic biopsies of brain lesions at our institution between June 2015 and January 2024 were retrospectively reviewed. All patients were assessed using hematoxylin/eosin (HE) staining of intraoperative frozen sections, and intraoperative immunohistochemical examination when necessary. A final diagnosis derived from integrated diagnostics (neoplastic diseases) or final histopathologic examination (non-neoplastic diseases) was the 'gold standard'. Intraoperative frozen section results were divided into 3 categories: confirmed diagnosis, tentative diagnosis, and misdiagnosis. Subgroup analyses of negative intraoperative frozen section results, tentative diagnoses or misdiagnoses were conducted stratified by lesion size and lesion type. Results: Mean turn-around time for intraoperative frozen sections was 26 ± 5.6 min (range, 20-62 min). 1 (FS-1) to 4 (FS-N) (median, 1) intraoperative frozen sections were evaluated per patient. There was a significant increase in positive results from FS-1 (79.77%; Conclusion: The diagnostic yield of intraoperative frozen sections obtained through robot-assisted stereotactic biopsy of brain lesions is high. If the first frozen section result is negative, additional specimens should be obtained after adjusting the puncture depth or the target. Lesions that are difficult to distinguish morphologically on HE staining may be examined using intraoperative immunohistochemistry. High-grade glioma may be more prone to tentative or misdiagnosis due to heterogeneity of the lesion.
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