Evidence map›Paper›PMID 40556646›Full record

ReviewEuropean cardiology2025

Oral P2Y

Elisabetta Bigagli, Jacopo Angelini, Alessandro Mugelli, Bianca Rocca

Abstract readReview
In one paragraph

Review in European cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Observational
  3. Observational
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Elisabetta BigagliDepartment of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence Florence, Italy.ORCID https://orcid.org/0000-0003-1892-4343
Jacopo AngeliniClinical Pharmacology and Toxicology Institute, University Hospital Friuli Centrale ASUFC Udine, Italy.ORCID https://orcid.org/0000-0002-8433-0394
Alessandro MugelliDepartment of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence Florence, Italy.ORCID https://orcid.org/0000-0002-1649-9702
Bianca RoccaDepartment of Medicine, LUM University, Casamassima Bari, Italy.ORCID https://orcid.org/0000-0001-8304-6423

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pharmacokinetic-based drug-drug interactions (DDI) largely contribute to therapeutic failures by decreasing a drug's safety or efficacy. In particular, clinically relevant DDIs generate major changes in plasma concentrations of the 'victim' drug exerted by the 'perpetrator' drug, which interferes with different pharmacokinetic steps. Polypharmacy significantly contributes to clinically relevant DDIs, but is unavoidable for complex patients, such as those with acute or chronic cardiovascular diseases with comorbidities. Oral P2Y

Indexed as

clopidogrelcytochrome P450drug–drug interactionsdrug transportersP2Y12 inhibitorsprasugrelticagrelor

Identifiers

PMID40556646
PMCPMC12186167

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.