Evidence map›Paper›PMID 40556615›Full record

ArticleAddiction biology2025

Protein Associations With Alcohol Consumption and Genetic Risk for Alcohol-Related Sociomedical Conditions.

Gabin Drouard, Teemu Palviainen, Chia-Ling Kuo, Breno S Diniz, Xiaoling Wang, Miina Ollikainen, Antti Latvala, Jaakko Kaprio

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Addiction biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gabin DrouardInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-3227-8483
Teemu PalviainenInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-7847-8384
Chia-Ling KuoDepartment of Public Health Sciences, University of Connecticut Health Center, Farmington, Connecticut, USA.ORCID 0000-0003-4452-2380
Breno S DinizDepartment of Public Health Sciences, University of Connecticut Health Center, Farmington, Connecticut, USA.ORCID 0000-0003-0653-1905
Xiaoling WangGeorgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Miina OllikainenInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.ORCID 0000-0003-3661-7400
Antti LatvalaInstitute of Criminology and Legal Policy, University of Helsinki, Helsinki, Finland.ORCID 0000-0001-5695-117X
Jaakko KaprioInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-3716-2455

Funding

Research Education ComponentP30AG067988 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Richard H Fortinsky, GEORGE A KUCHEL · 2021 to 2026
$9.5M
A GENOME-WIDE METHYLATION STUDY ON ESSENTIAL HYPERTENSIONR01HL104125 · NHLBI · AUGUSTA UNIVERSITY · PI WANG, XIAOLING · 2011 to 2015
$2.9M
Academy of Finland 263278Academy of Finland 265240Academy of Finland 297908Academy of Finland 308248Academy of Finland 312073Academy of Finland 336832NHLBI NIH HHS R01 HL104125NIA NIH HHS P30 AG067988NIA NIH HHS P30AG067988NIH/NHLBI HL104125Sigrid Juséliuksen SäätiöUK Biobank data 92647
6 · The paper itself

Abstract

Studies investigating proteomic associations with alcohol consumption and the genetic links of these proteins to alcohol-related traits are scarce. The aims of our study were (1) to identify proteins associated with alcohol consumption and (2) to investigate the molecular pathways and genetics linking the identified proteins to alcohol consumption and related sociomedical conditions. We generated proteomic and genotypic data from blood samples of 387 Finnish twins (age range: 56-70) and calculated polygenic risk scores (PRSs) of eight alcohol-related traits: obesity, alcohol dependence, number of drinks per week, number of cigarettes per day, major depressive disorders (MDDs), schizophrenia, externalising behaviour and educational attainment. We identified 20 (out of 2321) proteins associated with alcohol consumption, expressed as log ethanol grams per month, after Bonferroni correction and adjustment for BMI, sex and age. Within-pair analyses in monozygotic twin pairs showed that some of the identified associations persisted after accounting for genetic confounding. While only the PRS representing genetic risk for the number of alcoholic drinks per week was associated with alcohol consumption, several proteins were associated with PRSs, in particular the PRS of MDD. All identified proteins were significantly replicated in the UK Biobank, and pathway analysis suggested their collective connection to alcohol consumption might be explained by oxidative stress and cell damage. In conclusion, we identified several alcohol-associated plasma proteins whose levels are also linked to genetic risk for mental illness and substance use. Our study suggests the potential of proteins as biomarkers for early detection of alcohol-related disorders.

Indexed as

Alcohol DrinkingAgedAlcoholismEducational StatusFemaleFinlandGenetic Predisposition to DiseaseGenotypeHumansMajor Depressive DisorderMaleMiddle AgedMultifactorial InheritanceObesityProteomicsRisk Factorsalcohol consumptiongeneticsmajor depressive disorderpolygenic risk scoresproteomicssubstance usetwins

Identifiers

PMID40556615
PMCPMC12188143

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.