ArticleBritish journal of haematology2025
Iron overload and morbidities in Chinese with non-transfusion-dependent thalassaemia.
Article in British journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Iron overload and morbidities in Chinese with non-transfusion-dependent thalassaemia.British journal of haematology · 2025Article
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20 authors.
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Abstract
Non-transfusion-dependent thalassaemia (NTDT) is associated with chronic health problems. A cross-sectional study was conducted in Hong Kong Chinese patients to evaluate the presentation and complications of NTDT. One hundred and nine patients aged between 6.7 and 72.3 years (median: 32 years), including 97 with α-thalassaemia intermedia and 12 with β-thalassaemia intermedia, were included from two public hospitals. Among them, 82% had never been transfused and 18% had received sporadic transfusions. Chelation therapy had been given to 7% of patients. Notably, 52% of patients had chronic health deficits with a strong positive correlation with advanced age, log-transformed ferritin levels and history of splenectomy. Hepatic iron overload was detected in 43% of patients, and extramedullary haematopoiesis in 14%. At least one endocrinopathy developed in 12% of patients. Patients with non-deletional α-thalassaemia intermedia and β-thalassaemia intermedia exhibited more severe disease than those with deletional α-thalassaemia intermedia. This study highlighted the need for ongoing monitoring and management strategies for NTDT to mitigate chronic health issues and improve outcomes.
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