ArticleEuropean journal of neurology2025
Structural Alterations Associated With Cardiovascular Autonomic Failure in Multiple System Atrophy.
Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- MRI-derived atrophy in multiple system atrophy aligns with mitochondrial and glial gene expression patterns.NPJ Parkinson's disease · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly severe autonomic failure (AF) in multiple system atrophy (MSA) is a risk factor for poor survival. Postmortem studies suggested that AF is related to the degeneration of preganglionic autonomic neurons of the brainstem and spinal cord.
objectivesCharacterize cerebral alterations on brain imaging associated with cardiovascular AF.
methodsCardiovascular sympathetic failure was evaluated through orthostatic hypotension (OH) based on changes in systolic and diastolic blood pressure during tilt-test (ΔSBP and ΔDBP). Reduced heart rate (HR) variability reflecting cardio-vagal impairment was assessed with a composite score formed by the root-mean square differences of successive R-R intervals (RMSSD) and HR changes during deep breathing. Voxel-based morphometry (SPM12), volumetry, and cortical thickness measurements (FreeSurfer 7.0) of T1-weighted anatomical images were used to assess gray matter (GM) atrophy in sub-tentorial structures. Multivariate analysis included age, disease severity (UMSARS), and total intracranial volume as confounding factors.
resultsA total of 62 MSA patients followed at the French Reference Center were retrospectively included, aged 67.3 ± 8.6 years, 69.4% MSA-P, disease duration 4.2 ± 2.1 years. Medulla atrophy was correlated to OH (p < 0.006). Decrease in GM volume in the left anterior cerebellum (lobule V) was correlated to ΔDBP (pFWEc = 0.017). GM loss in the left interposed nucleus was correlated to ΔSBP (p < 0.003), whereas atrophy of the right dentate was associated with decreased HR variability (p < 0.003).
conclusionMedulla volume was strongly correlated with OH. Cerebellar degeneration was associated with the severity of cardiovascular AF.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.