Evidence map›Paper›PMID 40556454›Full record

ArticleThe American journal of psychiatry2025

Grip Strength as a Marker of Resting-State Network Integrity and Well-Being in Early Psychosis.

Heather Burrell Ward, Adam Beermann, Karlos Manzanarez Felix, Lipika Narisetti, Kathryn E Lewandowski, Michael Coleman, Sylvain Bouix, Daphne Holt, Dost Öngür, Alan Breier and 3 more

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Article in The American journal of psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Heather Burrell WardDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville (Ward, Narisetti, Moussa-Tooks); Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Beerman, Manzanarez Felix, Brady); Department of Psychiatry, Harvard Medical School, Boston (Lewandowski, Coleman, Holt, Öngür, Shenton, Brady); McLean Hospital, Belmont, MA (Lewandowski, Öngür, Brady); Department of Psychiatry, Brigham and Women's Hospital, Boston (Coleman, Shenton); Department of Software Engineering and Information Technology, École de Technologie Supérieure, Montreal (Bouix); Department of Psychiatry, Massachusetts General Hospital, Boston (Holt); Department of Psychiatry, Indiana University School of Medicine, Indianapolis (Breier, Moussa-Tooks); Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington (Moussa-Tooks).ORCID 0000-0003-2901-8004
Adam BeermannDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville (Ward, Narisetti, Moussa-Tooks); Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Beerman, Manzanarez Felix, Brady); Department of Psychiatry, Harvard Medical School, Boston (Lewandowski, Coleman, Holt, Öngür, Shenton, Brady); McLean Hospital, Belmont, MA (Lewandowski, Öngür, Brady); Department of Psychiatry, Brigham and Women's Hospital, Boston (Coleman, Shenton); Department of Software Engineering and Information Technology, École de Technologie Supérieure, Montreal (Bouix); Department of Psychiatry, Massachusetts General Hospital, Boston (Holt); Department of Psychiatry, Indiana University School of Medicine, Indianapolis (Breier, Moussa-Tooks); Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington (Moussa-Tooks).
Karlos Manzanarez FelixDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville (Ward, Narisetti, Moussa-Tooks); Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Beerman, Manzanarez Felix, Brady); Department of Psychiatry, Harvard Medical School, Boston (Lewandowski, Coleman, Holt, Öngür, Shenton, Brady); McLean Hospital, Belmont, MA (Lewandowski, Öngür, Brady); Department of Psychiatry, Brigham and Women's Hospital, Boston (Coleman, Shenton); Department of Software Engineering and Information Technology, École de Technologie Supérieure, Montreal (Bouix); Department of Psychiatry, Massachusetts General Hospital, Boston (Holt); Department of Psychiatry, Indiana University School of Medicine, Indianapolis (Breier, Moussa-Tooks); Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington (Moussa-Tooks).
Lipika NarisettiDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville (Ward, Narisetti, Moussa-Tooks); Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Beerman, Manzanarez Felix, Brady); Department of Psychiatry, Harvard Medical School, Boston (Lewandowski, Coleman, Holt, Öngür, Shenton, Brady); McLean Hospital, Belmont, MA (Lewandowski, Öngür, Brady); Department of Psychiatry, Brigham and Women's Hospital, Boston (Coleman, Shenton); Department of Software Engineering and Information Technology, École de Technologie Supérieure, Montreal (Bouix); Department of Psychiatry, Massachusetts General Hospital, Boston (Holt); Department of Psychiatry, Indiana University School of Medicine, Indianapolis (Breier, Moussa-Tooks); Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington (Moussa-Tooks).
Kathryn E LewandowskiDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville (Ward, Narisetti, Moussa-Tooks); Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Beerman, Manzanarez Felix, Brady); Department of Psychiatry, Harvard Medical School, Boston (Lewandowski, Coleman, Holt, Öngür, Shenton, Brady); McLean Hospital, Belmont, MA (Lewandowski, Öngür, Brady); Department of Psychiatry, Brigham and Women's Hospital, Boston (Coleman, Shenton); Department of Software Engineering and Information Technology, École de Technologie Supérieure, Montreal (Bouix); Department of Psychiatry, Massachusetts General Hospital, Boston (Holt); Department of Psychiatry, Indiana University School of Medicine, Indianapolis (Breier, Moussa-Tooks); Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington (Moussa-Tooks).
Michael ColemanDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville (Ward, Narisetti, Moussa-Tooks); Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Beerman, Manzanarez Felix, Brady); Department of Psychiatry, Harvard Medical School, Boston (Lewandowski, Coleman, Holt, Öngür, Shenton, Brady); McLean Hospital, Belmont, MA (Lewandowski, Öngür, Brady); Department of Psychiatry, Brigham and Women's Hospital, Boston (Coleman, Shenton); Department of Software Engineering and Information Technology, École de Technologie Supérieure, Montreal (Bouix); Department of Psychiatry, Massachusetts General Hospital, Boston (Holt); Department of Psychiatry, Indiana University School of Medicine, Indianapolis (Breier, Moussa-Tooks); Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington (Moussa-Tooks).
Sylvain BouixDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville (Ward, Narisetti, Moussa-Tooks); Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Beerman, Manzanarez Felix, Brady); Department of Psychiatry, Harvard Medical School, Boston (Lewandowski, Coleman, Holt, Öngür, Shenton, Brady); McLean Hospital, Belmont, MA (Lewandowski, Öngür, Brady); Department of Psychiatry, Brigham and Women's Hospital, Boston (Coleman, Shenton); Department of Software Engineering and Information Technology, École de Technologie Supérieure, Montreal (Bouix); Department of Psychiatry, Massachusetts General Hospital, Boston (Holt); Department of Psychiatry, Indiana University School of Medicine, Indianapolis (Breier, Moussa-Tooks); Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington (Moussa-Tooks).
Daphne HoltDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville (Ward, Narisetti, Moussa-Tooks); Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Beerman, Manzanarez Felix, Brady); Department of Psychiatry, Harvard Medical School, Boston (Lewandowski, Coleman, Holt, Öngür, Shenton, Brady); McLean Hospital, Belmont, MA (Lewandowski, Öngür, Brady); Department of Psychiatry, Brigham and Women's Hospital, Boston (Coleman, Shenton); Department of Software Engineering and Information Technology, École de Technologie Supérieure, Montreal (Bouix); Department of Psychiatry, Massachusetts General Hospital, Boston (Holt); Department of Psychiatry, Indiana University School of Medicine, Indianapolis (Breier, Moussa-Tooks); Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington (Moussa-Tooks).
Dost ÖngürDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville (Ward, Narisetti, Moussa-Tooks); Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Beerman, Manzanarez Felix, Brady); Department of Psychiatry, Harvard Medical School, Boston (Lewandowski, Coleman, Holt, Öngür, Shenton, Brady); McLean Hospital, Belmont, MA (Lewandowski, Öngür, Brady); Department of Psychiatry, Brigham and Women's Hospital, Boston (Coleman, Shenton); Department of Software Engineering and Information Technology, École de Technologie Supérieure, Montreal (Bouix); Department of Psychiatry, Massachusetts General Hospital, Boston (Holt); Department of Psychiatry, Indiana University School of Medicine, Indianapolis (Breier, Moussa-Tooks); Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington (Moussa-Tooks).
Alan BreierDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville (Ward, Narisetti, Moussa-Tooks); Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Beerman, Manzanarez Felix, Brady); Department of Psychiatry, Harvard Medical School, Boston (Lewandowski, Coleman, Holt, Öngür, Shenton, Brady); McLean Hospital, Belmont, MA (Lewandowski, Öngür, Brady); Department of Psychiatry, Brigham and Women's Hospital, Boston (Coleman, Shenton); Department of Software Engineering and Information Technology, École de Technologie Supérieure, Montreal (Bouix); Department of Psychiatry, Massachusetts General Hospital, Boston (Holt); Department of Psychiatry, Indiana University School of Medicine, Indianapolis (Breier, Moussa-Tooks); Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington (Moussa-Tooks).
Martha E ShentonDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville (Ward, Narisetti, Moussa-Tooks); Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Beerman, Manzanarez Felix, Brady); Department of Psychiatry, Harvard Medical School, Boston (Lewandowski, Coleman, Holt, Öngür, Shenton, Brady); McLean Hospital, Belmont, MA (Lewandowski, Öngür, Brady); Department of Psychiatry, Brigham and Women's Hospital, Boston (Coleman, Shenton); Department of Software Engineering and Information Technology, École de Technologie Supérieure, Montreal (Bouix); Department of Psychiatry, Massachusetts General Hospital, Boston (Holt); Department of Psychiatry, Indiana University School of Medicine, Indianapolis (Breier, Moussa-Tooks); Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington (Moussa-Tooks).
Roscoe O BradyDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville (Ward, Narisetti, Moussa-Tooks); Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Beerman, Manzanarez Felix, Brady); Department of Psychiatry, Harvard Medical School, Boston (Lewandowski, Coleman, Holt, Öngür, Shenton, Brady); McLean Hospital, Belmont, MA (Lewandowski, Öngür, Brady); Department of Psychiatry, Brigham and Women's Hospital, Boston (Coleman, Shenton); Department of Software Engineering and Information Technology, École de Technologie Supérieure, Montreal (Bouix); Department of Psychiatry, Massachusetts General Hospital, Boston (Holt); Department of Psychiatry, Indiana University School of Medicine, Indianapolis (Breier, Moussa-Tooks); Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington (Moussa-Tooks).
Alexandra B Moussa-TooksDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville (Ward, Narisetti, Moussa-Tooks); Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Beerman, Manzanarez Felix, Brady); Department of Psychiatry, Harvard Medical School, Boston (Lewandowski, Coleman, Holt, Öngür, Shenton, Brady); McLean Hospital, Belmont, MA (Lewandowski, Öngür, Brady); Department of Psychiatry, Brigham and Women's Hospital, Boston (Coleman, Shenton); Department of Software Engineering and Information Technology, École de Technologie Supérieure, Montreal (Bouix); Department of Psychiatry, Massachusetts General Hospital, Boston (Holt); Department of Psychiatry, Indiana University School of Medicine, Indianapolis (Breier, Moussa-Tooks); Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington (Moussa-Tooks).ORCID 0000-0002-6778-8379

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3M
Institutional Career Development CoreKL2TR002245 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Julie A. Bastarache · 2017 to 2026
$9.3M
Academic-Community EPINET (AC-EPINET): Mitigating Barriers to CareR01MH120588 · NIMH · INDIANA UNIVERSITY INDIANAPOLIS · PI BREIER, ALAN · 2020 to 2023
$5.8M
Human Connectome Project for Early PsychosisU01MH109977 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI BREIER, ALAN, SHENTON, MARTHA E. · 2016 to 2020
$5.5M
Network Mediation of Experiential and Expressive Deficits in Psychotic DisordersR01MH116170 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Roscoe O. Brady, KATHRYN Eve LEWANDOWSKI · 2019 to 2026
$5.4M
Neuroprogression across the Psychosis Spectrum in the Early Course of IllnessR01MH117012 · NIMH · MCLEAN HOSPITAL · PI LEWANDOWSKI, KATHRYN EVE · 2019 to 2023
$2.4M
Longitudinal Assessment of Distinct Motor Learning Processes to Inform Mechanistic Models of Sensorimotor Function in PsychosisK23MH135215 · NIMH · TRUSTEES OF INDIANA UNIVERSITY · PI MOUSSA-TOOKS, ALEXANDRA · 2024 to 2025
$1.0M
Network-Targeted Neuromodulation for Nicotine Dependence in SchizophreniaK23DA059690 · NIDA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Heather Burrell Ward · 2024 to 2026
$557k
NCATS NIH HHS KL2 TR002245NICHD NIH HHS P50 HD103537NIDA NIH HHS K23 DA059690NIMH NIH HHS K23 MH135215NIMH NIH HHS R01 MH116170NIMH NIH HHS R01 MH117012NIMH NIH HHS R01 MH120588NIMH NIH HHS U01 MH109977
6 · The paper itself

Abstract

objectivePsychomotor function is a critical marker of risk and outcome of psychosis. Grip strength is one aspect of psychomotor function that is known to be linked to structural neural integrity and well-being. This study sought to determine whether grip strength is a marker of alterations in resting-state connectivity and well-being in psychotic disorders in order to further clarify the mechanisms by which psychosis phenomenology is related to psychomotor processes.

methodsThe authors analyzed resting-state functional MRI and grip strength in 89 individuals with early psychosis and 51 control subjects without psychiatric disorders from the Human Connectome Project for Early Psychosis. Participants ranged in age from 16 to 35 years. Using multivariate pattern analysis of whole-connectome data, the authors identified brain correlates of grip strength and then replicated this analysis using the NIH Toolbox well-being measures and the Global Assessment of Functioning Scale (GAF).

resultsThe psychosis group exhibited reduced grip strength, well-being, and GAF scores compared to the control group. Grip strength was linked to resting-state connectivity in the sensorimotor cortex, anterior cingulate cortex, and cerebellum. Connectivity correlated with the default mode network (DMN) (r

conclusionsData-driven, connectome-wide analysis identified shared brain correlates of grip strength, overall function, and well-being in a sample of young adults with psychosis and healthy control subjects. This suggests that grip strength may be a marker of DMN connectivity, which may in turn be an important marker of overall health, even in young adult populations.

Indexed as

BrainDefault Mode NetworkHand StrengthNerve NetPsychotic DisordersAdolescentAdultCerebellumConnectomeFemaleGyrus CinguliHumansMagnetic Resonance ImagingMaleSensorimotor CortexYoung AdultCognitive NeuroscienceNeuroimagingSchizophrenia Spectrum and Other Psychotic Disorders

Identifiers

PMID40556454
PMCPMC12323693

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.