Evidence map›Paper›PMID 40556426›Full record

ArticleAutophagy2025

NAD

Mahmoud Abdellatif, Francisco Vasques-Nóvoa, João Pedro Ferreira, Junichi Sadoshima, Abhinav Diwan, Wolfgang A Linke, Guido Kroemer, Simon Sedej

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mahmoud AbdellatifDepartment of Cardiology, Medical University of Graz, Graz, Austria.ORCID 0000-0002-5042-9054
Francisco Vasques-NóvoaDepartment of Internal Medicine, Centro Hospitalar Universitário de São João, Porto, Portugal.
João Pedro FerreiraDepartment of Internal Medicine, Centro Hospitalar Universitário de São João, Porto, Portugal.
Junichi SadoshimaDepartment of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.
Abhinav DiwanDivision of Cardiology and Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO, USA.
Wolfgang A LinkeInstitute of Physiology II, University of Münster, Münster, Germany.
Guido KroemerUniversité Paris Cité, Sorbonne Université, Inserm, Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Institut Universitaire de France, Paris, France.ORCID 0000-0002-9334-4405
Simon SedejDepartment of Cardiology, Medical University of Graz, Graz, Austria.ORCID 0000-0002-4419-6821

Funding

ROLE OF AUTOPHAGIC FLUX IN CARDIAC MYOCYTE VIABILITYR01HL107594 · NHLBI · WASHINGTON UNIVERSITY · PI Abhinav Diwan · 2011 to 2026
$5.9M
BLRD VA I01 BX005981NHLBI NIH HHS R01 HL107594
6 · The paper itself

Abstract

Macroautophagy/autophagy is markedly inhibited in the hearts of elderly obese patients with heart failure and preserved ejection fraction (HFpEF). However, the therapeutic relevance and underlying signaling mechanisms of the decline of autophagy in HFpEF remain unclear. We observed that therapeutic nicotinamide adenine dinucleotide (NAD

Indexed as

AutophagyCardiotonic AgentsHeart FailureMitophagyNADObesitySignal TransductionAnimalsAutophagy-Related Protein 5HumansInsulinInsulin-Like Growth Factor IMaleMiceMice, Inbred C57BLMyocytes, CardiacAutophagy-Related Protein 5Cardiotonic AgentsInsulinInsulin-Like Growth Factor INADNiacinamideAcetylationHFpEFIGF1insulinnutrient signalingsirtuins

Identifiers

PMID40556426
PMCPMC12459361

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.