Evidence map›Paper›PMID 40556424›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2025

Discovery of

Sahachai Sabuakham, Sutita Nasoontorn, Napat Nuramrum, Atit Silsirivanit, Thanyada Rungrotmongkol, Ratchanok Pingaew, Panupong Mahalapbutr

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sahachai SabuakhamDepartment of Biochemistry, Center for Translational Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Sutita NasoontornDepartment of Biochemistry, Center for Translational Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Napat NuramrumDepartment of Biochemistry, Center for Translational Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Atit SilsirivanitDepartment of Biochemistry, Center for Translational Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Thanyada RungrotmongkolProgram in Bioinformatics and Computational Biology, Graduate School, Chulalongkorn University, Bangkok, Thailand.
Ratchanok PingaewDepartment of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, Thailand.
Panupong MahalapbutrDepartment of Biochemistry, Center for Translational Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.ORCID 0000-0003-4389-334X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tyrosinase, a key enzyme in melanin synthesis, serves as a primary target for developing depigmenting agents. The search for novel tyrosinase inhibitors is needed due to the adverse effects of current inhibitors. This study evaluated 16

Indexed as

Drug DiscoveryEnzyme InhibitorsMonophenol MonooxygenaseThioureaAgaricalesAnimalsCell Line, TumorDose-Response Relationship, DrugMelaninsMiceMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureStructure-Activity RelationshipEnzyme InhibitorsMelaninsMonophenol MonooxygenaseThioureaBis-thioureascomputational biologymolecular dockingmolecular dynamics simulationstyrosinase

Identifiers

PMID40556424
PMCPMC12897533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.