Evidence map›Paper›PMID 40555962›Full record

ArticleCell biochemistry and biophysics2025

Identification of Transforming Growth Factor-β3 Signaling by Compressive Force in MC3T3-E1 Cells Reactions.

Moeko Togawa, Akira Nakajima, Nichika Fukumashi, Takayuki Kawato

Abstract read
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In one paragraph

Article in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Moeko TogawaDepartment of Orthodontics, Nihon University School of Dentistry, Chiyoda-ku, Tokyo, Japan.
Akira NakajimaDepartment of Orthodontics, Nihon University School of Dentistry, Chiyoda-ku, Tokyo, Japan. nakajima.akira@nihon-u.ac.jp.
Nichika FukumashiDepartment of Orthodontics, Nihon University School of Dentistry, Chiyoda-ku, Tokyo, Japan.
Takayuki KawatoDepartment of Oral Health Sciences, Nihon University School of Dentistry, Tokyo, Japan.

Funding

JSPS KAKENHI JP22K10280
6 · The paper itself

Abstract

The function of Transforming growth factor (TGF) -β is reported to be associated with bone formation. However, the functional role of TGF-β3 in mediating the effects of orthodontic force such as the compressive force as a mechanical stress on osteoblasts remains unclear. We investigated the expression of TGF-β3 in osteoblasts and the effect of compressive force on downstream signaling pathways consisting of inflammatory cytokines and bone-specific transcription factors. Cultured MC3T3-E1 cells were subjected to continuous compressive forces, which are 0.5, 1.0, 2.0 g/cm

Indexed as

OsteoblastsSignal TransductionStress, MechanicalTransforming Growth Factor beta3AnimalsCell LineCore Binding Factor Alpha 1 SubunitCyclooxygenase 2Interleukin-6MicePhosphorylationRNA, Small InterferingSmad2 ProteinSmad3 ProteinSmad ProteinsCore Binding Factor Alpha 1 SubunitCyclooxygenase 2Interleukin-6RNA, Small InterferingRunx2 protein, mouseSmad2 ProteinSmad3 ProteinSmad ProteinsTransforming Growth Factor beta3compressing forceMAPK signalingMC3T3-E1 cellsSmad-independent signalingTGF-β3 signalingTooth movement

Identifiers

PMID40555962

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.