Evidence map›Paper›PMID 40555938›Full record

Trial reportNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Cost-efficacy evaluation of a mindfulness-based program added to treatment as usual for the treatment of chronic migraine associated to medication overuse headache.

Alberto Raggi, Domenico D'Amico, Erika Guastafierro, Emilio Ciusani, Danilo Antonio Montisano, Alessandra Erbetta, Greta Demichelis, Davide Fedeli, Anna Nigri, Licia Grazzi

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03671681 (A Randomized Clinical Trial on the Efficacy and Cost-efficacy of Adding on a Mindfulness-based Therapy to Standard Medical Prophylaxis in the Treatment of Patients With Chronic Migraine Associated to Medication Overuse Following Structured Withdrawal), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03671681 phase4completednot on this map

A Randomized Clinical Trial on the Efficacy and Cost-efficacy of Adding on a Mindfulness-based Therapy to Standard Medical Prophylaxis in the Treatment of Patients With Chronic Migraine Associated to Medication Overuse Following Structured Withdrawal: the Mind-CM Study

TypeinterventionalSponsorFondazione I.R.C.C.S. Istituto Neurologico Carlo BestaRan2018 to 2023Enrolled177ConditionsChronic Migraine, Medication Overuse HeadacheArmsMindfulness, Prophylactic
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alberto RaggiNeurology, Public Health and Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, Milano, 20133, Italy. alberto.raggi@istituto-besta.it.ORCID http://orcid.org/0000-0002-7433-7779
Domenico D'AmicoNeuroalgology Unit and Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.ORCID http://orcid.org/0000-0002-5016-9301
Erika GuastafierroNeurology, Public Health and Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, Milano, 20133, Italy.ORCID http://orcid.org/0000-0002-5051-0207
Emilio CiusaniDepartment of Diagnostic and Technology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.ORCID http://orcid.org/0000-0002-7285-123X
Danilo Antonio MontisanoNeuroalgology Unit and Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.ORCID http://orcid.org/0000-0003-4834-2045
Alessandra ErbettaDepartment of Neuroradiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.ORCID http://orcid.org/0000-0003-3155-4850
Greta DemichelisDepartment of Neuroradiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.ORCID http://orcid.org/0000-0003-2034-0283
Davide FedeliDepartment of Neuroradiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.ORCID http://orcid.org/0000-0001-9732-2353
Anna NigriDepartment of Neuroradiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.ORCID http://orcid.org/0000-0002-1197-5458
Licia GrazziNeuroalgology Unit and Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.ORCID http://orcid.org/0000-0001-6535-1109

Funding

Ministero della Salute RF-2016-02364801
6 · The paper itself

Abstract

backgroundChronic Migraine associated to Medication Overuse Headache (CM-MOH) causes considerable costs in reason of healthcare costs and loss of productivity. Recently, a mindfulness-based program added to treatment as usual (TaU) proved efficacy compared to TaU alone in patients with CM-MOH. This study aims to assess the cost-efficacy of such multimodal treatment protocol.

methodsPatients with CM-MOH filled in a specific protocol aimed to assess direct healthcare costs, direct non-medical costs, and indirect costs, referred to the three months before starting the treatment protocol. Repeated measure analyses were employed to compare total costs’ reductions between the two group of patients. Then, we compared the delta in total costs after allocation to the two treatment arms using the independent-sample t-test.

results154 patients completed the 12-months follow-up. Over the period, CM-MOH cost was reduced from 2620€ (95% CI: 2146–3094€) to 1603€ (95% CI: 1182–2023€) in the TaU group, and from 2978€ (95% CI: 2293–3656€) to 752€ (95% CI: 539–965€) in the TaU + MIND group. The time*group interaction analysis on cost reduction indicated a significant difference (F = 2.953,149; p =.035) with a moderate effect size (partial η2 = 0.056). The average difference on one-year cost after randomization was 2582€ favoring patients in the TaU + MIND group: such a figure is higher than the reimbursement from the Lombardia Region Health System for mindfulness-based sessions implementation (57€ per patient).

conclusionsThis study supports the cost-efficacy of adding six weekly group sessions of mindfulness practice to TaU for the treatment of CM-MOH.

trial registrationNCT03671681 (clinicaltrials.gov 13/09/2018).

Indexed as

Cost-Benefit AnalysisHeadache Disorders, SecondaryHealth Care CostsMigraine DisordersMindfulnessAdultChronic DiseaseCombined Modality TherapyCost-Effectiveness AnalysisFemaleFollow-Up StudiesHumansMaleMiddle AgedTreatment OutcomeChronic migraineCost-efficacy evaluationDirect healthcare costIndirect costMedication overuse headacheMindfulness

Identifiers

PMID40555938

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.