Evidence map›Paper›PMID 40555914›Full record

ArticleBreast cancer (Tokyo, Japan)2025

KLF13 promotes breast cancer progression through the HTRA1 and the Hedgehog signaling pathway.

Meiling Huang, Jian Zhang, Changjiao Yan, Rui Ling, Ting Wang

Abstract read
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In one paragraph

Article in Breast cancer (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Breast cancer stem cell activity driven byWorld journal of stem cells · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Meiling Huang *Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, People's Republic of China.
Jian Zhang *State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, 710032, People's Republic of China.
Changjiao YanDepartment of Thyroid, Breast and Vascular Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, People's Republic of China.
Rui LingDepartment of Thyroid, Breast and Vascular Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, People's Republic of China. lingruiaoxue@126.com.
Ting WangDepartment of Thyroid, Breast and Vascular Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, People's Republic of China. ting_w100@126.com.ORCID http://orcid.org/0000-0003-4121-7532

Funding

The Natural Science Foundation of Shaanxi Province No. 2023-JC-QN-0965
6 · The paper itself

Abstract

backgroundKruppel-like factor 13 (KLF13) influences both immune system disorders and cancer progression, whereas the effects of KLF13 on the immune escape and breast cancer remain incompletely understood. RESEARCH DESIGN AND

methodsKLF13 expression was assessed in breast cancer tumor tissues. The roles of KLF13 in cell proliferation, migration, and immune evasion were assessed. RNA sequencing was used to identify the differentially expressed genes and signaling. Chip-seq and luciferase assays were performed to validate binding of KLF13 to its downstream genes. In vivo studies were conducted to confirm the function of KLF13. The mechanisms were elucidated using recovery assays.

resultsKLF13 levels were higher in breast cancer tissue. Silencing KLF13 markedly diminished cell proliferation, migration, mammosphere formation, and immune evasion by suppressing the levels of HTRA1 and the Hedgehog signaling pathway. KLF13 overexpression potentiated breast cancer aggressiveness and enhanced immune evasion. Inhibiting KLF13 delayed development of cancer xenografts, as well as curtailing tumor growth, which were reversed by co-expression of HTRA1. Clinical relevance results suggested a positive correlation between KLF13, HTRA1 and density of CD8T cells in human breast cancer patients.

conclusionsKLF13 can serve as a tumor promoter in breast cancer by influencing HTRA1 and the Hedgehog signaling pathway.

Indexed as

Breast NeoplasmsHedgehog ProteinsHigh-Temperature Requirement A Serine Peptidase 1Kruppel-Like Transcription FactorsRepressor ProteinsAnimalsCell Line, TumorCell MovementCell ProliferationDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMiceSignal TransductionTumor EscapeHedgehog ProteinsHigh-Temperature Requirement A Serine Peptidase 1HTRA1 protein, humanKruppel-Like Transcription FactorsRepressor ProteinsBreast cancerHedgehog signaling pathwayHigh temperature requirement A1Immune escapeKrüppel-like factor 13

Identifiers

PMID40555914

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.