ArticleReproductive sciences (Thousand Oaks, Calif.)2025
m5C-Modified lncRNA SNHG15 Promotes Ovarian Cancer Progression Via the miR-545-3p/PD-L1 Axis.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Emerging roles of RNA N5-methylcytosine modification in reproductive physiology and gynecological diseases.Epigenetics · 2026Review
- 5-Methylcytidine RNA Epitranscriptomics in Women's Health and Disease: Mechanisms and Clinical Implications.Cells · 2026Review
- NSUNs-driven dysregulation: the next frontier in targeted cancer therapy?Cell death & disease · 2025Review
- Roles and mechanisms of NSUN2-mediated RNA mFrontiers in immunology · 2025Review
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Authors and funding
6 authors.
Funding
Abstract
Ovarian cancer (OC) poses a health burden of women. Long non-coding RNA SNHG15 has been reported to promote OC progression; however, its effect on immune evasion remains unknown. Here, we investigated the effect of SNHG15 on OC cell immune evasion and the underlying mechanism. Cell phenotypes were assessed using cell counting kit-8, colony formation, lactate dehydrogenase cytotoxicity, and enzyme-linked immunosorbent assays. The mechanism was evaluated by dual-luciferase reporter assay, RNA pull-down, RNA immunoprecipitation (RIP), methylated RIP, and RNA stability assay. The role in vivo was analyzed using tumor-bearing mice. The results showed that SNHG15 and PD-L1 levels were increased, while miR-545-3p expression was reduced in OC. SNHG15 was a sponge of miR-545-3p, and PD-L1 was a downstream target of SNHG15. Knockdown of SNHG15 suppressed OC cell proliferation, and enhanced cytotoxicity and pro-inflammatory response of CD8
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