Evidence map›Paper›PMID 40555874›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Effectiveness of an online mindfulness-based stress-reduction intervention to reduce anxiety in breast cancer survivors: a randomized-controlled trial.

Ana Ferrigno Guajardo, Misael Salazar-Alejo, Fernanda Mesa-Chavez, Javier Gutierrez-Ornelas, Alejandra Platas, Haydee Verduzco-Aguirre, Cynthia Villarreal-Garza

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05837169 (Randomized Study with Wait-list Control to Evaluate the Impact of a Stress Reduction Intervention Based on Mindfulness Offered Virtually to Reduce Anxiety Levels in Breast Cancer Survivors), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05837169 nacompletednot on this map

Randomized Study with Wait-list Control to Evaluate the Impact of a Stress Reduction Intervention Based on Mindfulness Offered Virtually to Reduce Anxiety Levels in Breast Cancer Survivors

TypeinterventionalSponsorMedicos e Investigadores en la Lucha contra el Cancer de MamaRan2021 to 2022Enrolled68ConditionsAnxiety, Breast Cancer, SurvivorshipArmsMindfulness-based stress reduction
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Effectiveness of eHealth interventions in long-term follow-up care for breast and gynecological cancer survivors: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  2. [Psychoeducation among women with breast cancer and emotional symptoms].Revista medica del Instituto Mexicano del Seguro Social · 2026
    Trial
  3. Review
  4. Review
  5. Article
  6. Breast cancer stem cell activity driven byWorld journal of stem cells · 2026
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ana Ferrigno GuajardoDepartment of Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-1855-1196
Misael Salazar-AlejoTecnologico de Monterrey, Breast Cancer Center, Hospital Zambrano Hellion TecSalud, Av. Batallon de San Patricio 112, San Pedro Garza Garcia, NL, Mexico.ORCID http://orcid.org/0000-0002-9389-639X
Fernanda Mesa-ChavezTecnologico de Monterrey, Breast Cancer Center, Hospital Zambrano Hellion TecSalud, Av. Batallon de San Patricio 112, San Pedro Garza Garcia, NL, Mexico.ORCID http://orcid.org/0000-0003-4723-1837
Javier Gutierrez-OrnelasCentro Mindfulness Monterrey, San Pedro Garza García, Mexico.
Alejandra PlatasMedicos E Investigadores en La Lucha Contra El Cancer de Mama (MILC), Mexico City, Mexico.
Haydee Verduzco-AguirreDepartment of Oncology, Queens University, Kingston, ON, Canada.ORCID http://orcid.org/0000-0002-2300-7075
Cynthia Villarreal-GarzaTecnologico de Monterrey, Breast Cancer Center, Hospital Zambrano Hellion TecSalud, Av. Batallon de San Patricio 112, San Pedro Garza Garcia, NL, Mexico. cynthia.villarreal@tecsalud.mx.ORCID http://orcid.org/0000-0003-3587-339X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study evaluated the efficacy of an online mindfulness-based stress reduction (MBSR) intervention in reducing anxiety among breast cancer (BC) survivors, leveraging the potential advantages of digital delivery to enhance psychosocial care for this population.

methodsIn this randomized controlled trial, 68 BC survivors with elevated anxiety levels were assigned to either an 8-week online MBSR intervention (n = 33) or a waitlist control group (n = 35). Anxiety (GAD-7), depression (PHQ-9), fatigue (FACIT-F), insomnia (ISI), cancer-related worry (CWS), vasomotor symptoms (MENQOL), and mindful awareness (MAAS) were assessed at baseline, post-intervention, and at 5- and 8-months follow-up.

resultsCompared to the control group, MBSR participants showed significant reductions in anxiety (mean difference -4.13 points, 95CI -6.79 to -1.46, p = 0.003), depression (mean score difference -6.03, p < 0.001), fatigue (mean difference + 6.03, p = 0.002), insomnia (mean difference -3.97, p = 0.026), and cancer-related worry (mean difference -4.57, p = 0.003) at post-intervention, but no change in vasomotor symptoms (p > 0.05). MBSR participants also demonstrated increased mindful awareness (mean difference + 1.00, p = 0.004) that persisted through follow-up. The proportion of participants with clinically significant anxiety decreased from 96% pre-intervention to 38% at 8-months follow-up in the MBSR group, compared to relatively stable rates (88% to 87%) in the control group.

conclusionsOnline MBSR is a potentially effective intervention for reducing anxiety and improving psychological well-being in BC survivors. This accessible format may help overcome barriers to psychosocial care for cancer survivors. CLINICALTRIALS: GOV ID: NCT05837169.

Indexed as

AnxietyBreast NeoplasmsCancer SurvivorsMindfulnessStress, PsychologicalAdultAgedDepressionFatigueFemaleHumansInternet-Based InterventionMiddle AgedSleep Initiation and Maintenance DisordersAnxietyBreast cancerDepressionFatigueInsomniaMindfulnessSurvivorship

Identifiers

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.