Evidence map›Paper›PMID 40555871›Full record

ArticleTropical animal health and production2025

Can early weaning in the previous lactation of beef cows affect the metabolism and postnatal development of female offspring?

Thiago Kan Nishimura, Matheus Sousa de Paula Carlis, Ana Clara Degan Matos, Isabella Rio Feltrin, Rodrigo Silva Goulart, Germán Darío Ramírez Zamudio, Saulo Luz Silva, Arlindo Saran Netto, Paulo Roberto Leme, Guilherme Pugliesi

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In one paragraph

Article in Tropical animal health and production, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Thiago Kan NishimuraDepartment of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Pirassununga, 13635-900, Brazil.
Matheus Sousa de Paula CarlisDepartment of Animal Science, School of Animal Science and Food Engineering, University of São Paulo, São Paulo, Pirassununga, 13635-900, Brazil.
Ana Clara Degan MatosDepartment of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Pirassununga, 13635-900, Brazil.
Isabella Rio FeltrinDepartment of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Pirassununga, 13635-900, Brazil. isabella.feltrin@usp.br.ORCID http://orcid.org/0000-0001-9747-9385
Rodrigo Silva GoulartDepartment of Animal Science, School of Animal Science and Food Engineering, University of São Paulo, São Paulo, Pirassununga, 13635-900, Brazil.
Germán Darío Ramírez ZamudioDepartment of Animal Science, School of Animal Science and Food Engineering, University of São Paulo, São Paulo, Pirassununga, 13635-900, Brazil.
Saulo Luz SilvaDepartment of Animal Science, School of Animal Science and Food Engineering, University of São Paulo, São Paulo, Pirassununga, 13635-900, Brazil.
Arlindo Saran NettoDepartment of Animal Science, School of Animal Science and Food Engineering, University of São Paulo, São Paulo, Pirassununga, 13635-900, Brazil.
Paulo Roberto LemeDepartment of Animal Science, School of Animal Science and Food Engineering, University of São Paulo, São Paulo, Pirassununga, 13635-900, Brazil.
Guilherme PugliesiDepartment of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Pirassununga, 13635-900, Brazil.

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/18937-0
6 · The paper itself

Abstract

This study aimed to compare the effects of early weaning (EW; 150 days) and conventional weaning (CW; 240 days) during early pregnancy on the postnatal metabolism, development, and productive performance of female calves born from secondiparous (SEC) and multiparous (MULT) cows. Fifty-five Nelore female calves were evaluated: 25 from EW cows (10 SEC, 15 MULT) and 30 from CW cows (15 SEC, 15 MULT). From 90 to 150 days of age, all calves received creep feed (5 g/kg body weight [BW]). After weaning, calves were maintained on pasture and supplemented with 10 g/kg of BW of concentrate until 16 months (mo) of age. From 12 to 16 mo, heifers were assessed every 28 ± 3 days for BW, body condition score (BCS), and average daily gain (ADG), which was calculated from serial weight records. Carcass traits (ribeye area [REA], backfat thickness [BFT], and rump fat thickness [RFT]) were measured via ultrasound. Blood samples were collected to determine serum concentration of IGF-I, leptin, and plasma glucose. At 5 and 14 mo, a subgroup of 22 heifers (n = 10 for EW and 12 for CW) was selected for liver biopsy to assess the gene expression of IGF-I, IGFBP, and GHR. No significant interactions were found between dam parity, weaning strategy, or time for BW, BCS, ADG, REA, serum IGF-I, leptin, and plasma concentration for glucose (P > 0.1). A significant effect of time (P < 0.05) indicated increased in BW, BCS, LMA, BFT, and RTF throughout the experimental period. Heifers from MULT cows were 2.67 kg heavier between 13 to 15 mo than those from SEC cows (P = 0.04). Dam parity also influenced BCS (P = 0.01), with MULT-derived heifers presenting higher BCS than those from SEC cows. For carcass traits, a significant dam parity x weaning interaction was observed for RTF (P = 0.04), indicating that EW-SEC heifers had lower rump fat deposition compared to EW-MULT and CW heifers. IGF-I gene expression was 1.4-fold greater (P = 0.01) at 5 mo compared 14 mo. For IGFBP, a dam parity × time interaction (P = 0.05) revealed that heifers from MULT cows had a 1.8-fold higher expression at 14 mo than at 5 mo. In conclusion, early weaning in the preceding lactation did not negatively affect the subsequent offspring's performance or metabolic profile, except for a reduction in rump fat thickness in EW-SEC heifers.

Indexed as

LactationWeaningAnimal Nutritional Physiological PhenomenaAnimalsBody CompositionCattleFemaleInsulin-Like Growth Factor IPregnancyInsulin-Like Growth Factor IBeef cattleBody developmentHeiferNeloreNutritional status

Identifiers

PMID40555871

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.