Evidence map›Paper›PMID 40555855›Full record

ArticleMammalian genome : official journal of the International Mammalian Genome Society2025

FOXP2 mediates ZSCAN18 transcriptional activation to inhibit oral squamous cell carcinoma progression by blocking Hedgehog signaling.

Ling Niu, Guangyao Hu

Abstract read
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In one paragraph

Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ling NiuDepartment of Stomatology, Affiliated Hospital of Beihua University, No. 12, Jiefang Middle Road, Chuanying District, Jilin, 132011, Jilin, P.R. China.
Guangyao HuDepartment of Stomatology, Affiliated Hospital of Beihua University, No. 12, Jiefang Middle Road, Chuanying District, Jilin, 132011, Jilin, P.R. China. hugy3261@126.com.

Funding

the Science and technology research project of Jilin Provincial Department of education JJKH20230084KJ
6 · The paper itself

Abstract

Zinc finger and SCAN domain-containing (ZSCAN) family members have been implicated in cancer progression. This paper was to assess the role of ZSCAN18 in oral squamous cell carcinoma (OSCC). The OSCC datasets were obtained from the GEO database, and the differentially expressed gene ZSCAN18 was screened for the next analysis. ZSCAN18 protein levels in OSCC tissues and cell lines were investigated. ZSCAN18 was manually overexpressed in OSCC cells to analyze cell proliferation, invasion, migration, and stemness. The protein level of GLI1, a marker protein of the Hedgehog pathway, was detected to determine the effect of ZSCAN18 on this signaling pathway. A mouse xenograft tumor model was constructed to observe tumor growth. Rescue experiments were designed to validate the impact of the FOXP2/ZSCAN18 axis on OSCC. ZSCAN18 was lowly expressed in OSCC and predicted poor prognoses. ZSCAN18 overexpression inhibited OSCC progression, tumor cell stemness, and the Hedgehog pathway. FOXP2, an upstream transcription factor of ZSCAN18, transcriptionally activated ZSCAN18. Rescue experiments further confirmed that FOXP2 transcriptionally activated ZSCAN18 and thus inhibited stemness and tumor growth. Collectively, FOXP2 mediates ZSCAN18 transcriptional activation to inhibit OSCC by blocking Hedgehog signaling.

Indexed as

Carcinoma, Squamous CellForkhead Transcription FactorsHedgehog ProteinsMouth NeoplasmsTranscription FactorsAnimalsCell Line, TumorCell MovementCell ProliferationDisease ProgressionGene Expression Regulation, NeoplasticHumansMiceSignal TransductionTranscriptional ActivationZinc Finger Protein GLI1Forkhead Transcription FactorsFOXP2 protein, humanHedgehog ProteinsTranscription FactorsZinc Finger Protein GLI1FOXP2Hedgehog signaling pathwayOral squamous cell carcinomaTranscriptional activationZSCAN18

Identifiers

PMID40555855

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.