Evidence map›Paper›PMID 40555829›Full record

ArticleEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2025

Innovative approach to distraction osteogenesis using a novel external fixator design. In vivo experimental rabbit model.

Fathia Slimi, Awatef Hadj Bahri, Moez Trigui, Ahmed Racem Guidara, Zoubeir Ellouz, Tarek Rebai, Hafed Elfeki, Abdelfatteh Elfeki, Keskes Hassib, Jebahi Samira

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Article in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Fathia SlimiLaboratory Cell Therapy and Experimental Surgery of Musculoskeletal System, University of Sfax, LR18SP11, Sfax, Tunisia.
Awatef Hadj BahriLaboratory Cell Therapy and Experimental Surgery of Musculoskeletal System, University of Sfax, LR18SP11, Sfax, Tunisia.
Moez TriguiDepartment of Orthopedic and Trauma Surgery, Military University Hospital of Sfax, Military University Hospital of Sfax, Sfax, Tunisia.
Ahmed Racem GuidaraLaboratory Cell Therapy and Experimental Surgery of Musculoskeletal System, University of Sfax, LR18SP11, Sfax, Tunisia.
Zoubeir EllouzLaboratory Cell Therapy and Experimental Surgery of Musculoskeletal System, University of Sfax, LR18SP11, Sfax, Tunisia.
Tarek RebaiLaboratory Cell Therapy and Experimental Surgery of Musculoskeletal System, University of Sfax, LR18SP11, Sfax, Tunisia.
Hafed ElfekiLaboratory of Materials Science and Environment, Faculty of Sciences of Sfax, Sfax, Tunisia.
Abdelfatteh ElfekiLaboratory of Histo-Embryology & Cytogenetics, Medicine Faculty of Sfax, University of Sfax, Sfax, Tunisia.
Keskes HassibLaboratory Cell Therapy and Experimental Surgery of Musculoskeletal System, University of Sfax, LR18SP11, Sfax, Tunisia.
Jebahi SamiraHigh Institute of Applied Biology of Medicine, Gabes University, Gabes, Tunisia. jbahisamira@yahoo.Fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Distraction osteogenesis is an established surgical technique for bone lengthening. The procedure involves making osteotomies, in the bone and using a device to gradually separate, or "distract," the bone fragments. New Zealand white male rabbits underwent distraction osteogenesis on the right tibia and lengthening using external fixators at two different time points: a speed of 1.4 mm/day in 15 days and 2.1 mm/day in 10 days. Radiological analysis was used to determine the distraction osteogenesis rates during tibia lengthening in rabbits. The regenerated callus was carefully removed and subjected to biological and physicochemical analyses, such as scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), and nuclear magnetic resonance (NMR) analyses. For both groups, quantitative radiography showed that the distraction-induced deficiency was filled over time in a consistent manner. However, the amount of the newly formed tissue in rabbits of the fast-lengthening group was less significant than that of the fast group. For five weeks, FTIR results showed that the mineral phases of the regenerated tissue of two groups were made up of biological apatite crystals, which are defined as carbonated calcium phosphate. The IR spectra confirmed the presence of phosphate (PO

Indexed as

External FixatorsOsteogenesis, DistractionTibiaAnimalsBone RegenerationBony CallusEquipment DesignMagnetic Resonance SpectroscopyMaleMicroscopy, Electron, ScanningModels, AnimalRabbitsRadiographySpectroscopy, Fourier Transform InfraredDistraction osteogenesisHistological examinationMini-external fixatorOsteomy

Identifiers

PMID40555829

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.