Evidence map›Paper›PMID 40555725›Full record

ArticleTranslational psychiatry2025

Not just old wine in new bottles: Polygenic liability for ADHD is associated with electrophysiological affective-motivational processing beyond anxiety, depression, and ODD.

Kristóf Ágrez, Zsombor Visky, György Hámori, Mária Takács, Attila J Pulay, János M Réthelyi, Nóra Bunford

Abstract read
In one paragraph

Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Linking ADHD to Depression in Adolescents: the Mediating Role of Social Skills.Research on child and adolescent psychopathology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kristóf Ágrez *HUN-REN Research Centre for Natural Sciences, Clinical and Developmental Neuropsychology Research Group, Budapest, Hungary.ORCID http://orcid.org/0000-0002-4896-5966
Zsombor Visky *Semmelweis University, Faculty of Medicine, Budapest, Hungary.
György HámoriHUN-REN Research Centre for Natural Sciences, Clinical and Developmental Neuropsychology Research Group, Budapest, Hungary.
Mária TakácsHUN-REN Research Centre for Natural Sciences, Clinical and Developmental Neuropsychology Research Group, Budapest, Hungary.
Attila J PulaySemmelweis University, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Budapest, Hungary.
János M RéthelyiHUN-REN Research Centre for Natural Sciences, Clinical and Developmental Neuropsychology Research Group, Budapest, Hungary.ORCID http://orcid.org/0000-0002-3641-012X
Nóra BunfordHUN-REN Research Centre for Natural Sciences, Clinical and Developmental Neuropsychology Research Group, Budapest, Hungary. bunford.nora@ttk.hu.ORCID http://orcid.org/0000-0002-9645-604X

Funding

Magyar Tudományos Akadémia (Hungarian Academy of Sciences) HAS-ELRN NAP2022-I-2/2022Magyar Tudományos Akadémia (Hungarian Academy of Sciences) LP2018-3/2018
6 · The paper itself

Abstract

In attention-deficit/hyperactivity disorder (ADHD), emotional features account for heterogeneity and exacerbate severity of behavioral and functional impairments, beyond cognitive and comorbidity features. Yet, debate remains about the extent to which, in ADHD, such emotional features are a "core feature", i.e. whether ADHD should be conceptualized as encompassing difficulties with regulating not only activity, attention, and impulses but also processing and regulating emotions. We aimed to address this issue by examining the extent to which in adolescents, ADHD polygenic scores (PGSs) are associated with electrophysiological indices of affective-motivational processing, measured during a monetary punishment/reward feedback paradigm. ADHD PGSs were negatively associated, in n = 166 adolescents (M

Indexed as

AnxietyAttention Deficit and Disruptive Behavior DisordersAttention Deficit Disorder with HyperactivityDepressionEvoked PotentialsMotivationMultifactorial InheritanceAdolescentElectroencephalographyFemaleHumansMalePunishmentReward

Identifiers

PMID40555725
PMCPMC12187935

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.