Evidence map›Paper›PMID 40555621›Full record

Trial reportPatient education and counseling2026

How does addressing diabetes distress lead to positive glycemic change? Results from the EMBARK trial.

Lawrence Fisher, Susan Guzman, William H Polonsky, Lisa Strycker, Katherine Greenberg, Danielle M Hessler

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Patient education and counseling, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lawrence FisherUniversity of California, San Francisco, San Francisco, CA, United States. Electronic address: Larry.Fisher@ucsf.edu.
Susan GuzmanBehavioral Diabetes Institute, San Diego, CA, United States. Electronic address: sjg@behavioraldiabetes.org.
William H PolonskyBehavioral Diabetes Institute, San Diego, CA, United States. Electronic address: whp@behavioraldiabetes.org.
Lisa StryckerOregon Research Institute, Springfield, OR, United States. Electronic address: lisas@ori.org.
Katherine GreenbergUniversity of California, San Francisco, San Francisco, CA, United States. Electronic address: Katherine.Greenberg@ucsf.edu.
Danielle M HesslerUniversity of California, San Francisco, San Francisco, CA, United States. Electronic address: Danielle.hessler@ucsf.edu.

Funding

Evaluating Affective and Unified Behavioral Approaches to Reducing Diabetes Distress and Improving Glycemic ControlR01DK121241 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FISHER, LAWRENCE, HESSLER, DANIELLE MARIE · 2019 to 2022
$2.6M
NIDDK NIH HHS R01 DK121241
6 · The paper itself

Abstract

objectiveTo document the effectiveness of diabetes distress (DD) interventions and to suggest how the improvements in DD, documented in a previous report, led to improved glycemic outcomes.

methodsIndividuals with T1D (n = 276) with elevated DD (>2 on T1 Diabetes Distress Scale) and HbA1c (>7.5 %) were assigned to: (1) StreamLine, a diabetes self-management program; (2) TunedIn, an ACT-based (Acceptance and Commitment Therapy), emotion-focused DD program; or (3) FixIt, an integration of Streamline and TunedIn. Previous research had shown reduced DD (Stage 1) and improved glycemic outcomes (Stage 4) from baseline to 12-months. Here we assess two intermediate stages: adoption of a new emotional perspective (Stage 2) and improvements in diabetes-related problem solving (Stage 3). A structural equation model was specified to evaluate a hypothesized, 4-stage model of change.

resultsImprovements occurred in all three interventions at all 4 stages. TunedIn and FixIt, however, compared to StreamLine, displayed greater improvements in Stages 1 through 3; while StreamLine and TunedIn displayed greater improvements in glycemic outcomes than FixIt. Associations between reductions in DD and glycemic change were explained through improvements in emotional perspective taking and problem solving.

conclusionAlthough all three intervention groups showed improvement, TunedIn demonstrated the most comprehensive benefits. Findings indicate how reductions in diabetes distress, documented in a previous report, are linked with improved glycemic outcomes through changes in emotional perspective-taking, which then allow for improved diabetes-related problem solving. This sequence can form the basis for designing effective intervention programs to reduce DD and improve overall diabetes management.

Indexed as

Diabetes Mellitus, Type 1Psychological DistressSelf CareSelf-ManagementStress, PsychologicalAdultBlood GlucoseEmotionsFemaleGlycated HemoglobinGlycemic ControlHumansMaleMiddle AgedBlood GlucoseGlycated HemoglobinDiabetes distressGlycemic outcomesMechanisms of change

Identifiers

PMID40555621
PMCPMC13600257

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.