Evidence map›Paper›PMID 40555560›Full record

ArticleJournal for immunotherapy of cancer2025

Bystander CAR

Junichi Kato, Tatsuya Konishi, Takatsugu Honda, Masaki Maruta, Shogo Nabe, Yuya Masuda, Meika Matsumoto, Natsumi Kawasaki, Yukihiro Miyazaki, Yasukazu Doi and 4 more

Abstract readCase Reports
In one paragraph

Article in Journal for immunotherapy of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Junichi Kato *Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Tatsuya Konishi *Division of Blood Transfusion and Cell Therapy, Ehime University Hospital, Toon, Ehime, Japan.ORCID http://orcid.org/0000-0001-6203-9435
Takatsugu HondaDepartment of Clinical Laboratory, Ehime University Hospital, Toon, Ehime, Japan.
Masaki MarutaDepartment of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Shogo NabeDepartment of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Yuya MasudaDepartment of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Meika MatsumotoDepartment of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Natsumi KawasakiDepartment of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Yukihiro MiyazakiDepartment of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Yasukazu DoiDivision of Blood Transfusion and Cell Therapy, Ehime University Hospital, Toon, Ehime, Japan.
Yasunori TakasukaDepartment of Clinical Laboratory, Ehime University Hospital, Toon, Ehime, Japan.
Jun YamanouchiDivision of Blood Transfusion and Cell Therapy, Ehime University Hospital, Toon, Ehime, Japan.
Toshiki OchiDepartment of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan ochi.toshiki.eg@ehime-u.ac.jp takenaka.katsuto.hy@ehime-u.ac.jp.ORCID http://orcid.org/0000-0001-8440-6144
Katsuto TakenakaDepartment of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan ochi.toshiki.eg@ehime-u.ac.jp takenaka.katsuto.hy@ehime-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although bispecific antibody (BsAb) treatment is a valuable therapeutic option for post chimeric antigen receptor (CAR)-T cell therapy against relapsed/refractory large B-cell lymphoma, it remains to be clarified why it is still effective after intensive T-cell redirection therapy. Recently, the therapeutic potential of bystander CD8

Indexed as

Antibodies, BispecificCD8-Positive T-LymphocytesImmunotherapy, AdoptiveLymphoma, Large B-Cell, DiffuseReceptors, Chimeric AntigenBystander EffectHumansAntibodies, BispecificReceptors, Chimeric AntigenBispecific antibody - BsAbChimeric antigen receptor - CARImmunotherapyT cell

Identifiers

PMID40555560
PMCPMC12198839

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.