Evidence map›Paper›PMID 40555520›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Hearing Loss and Audiogenic Seizures Induced by Hypofunctional Prestin Variants.

Satoe Takahashi, Yingjie Zhou, Frédéric Dépreux, Donna S Whitlon, Mary Ann Cheatham, Kazuaki Homma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Satoe TakahashiDepartment of Otolaryngology - Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.ORCID 0000-0003-4264-3023
Yingjie ZhouDepartment of Communication Sciences and Disorders, Northwestern University, Evanston, Illinois 60208.
Frédéric DépreuxDepartment of Otolaryngology - Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
Donna S WhitlonDepartment of Otolaryngology - Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.ORCID 0000-0003-4169-9367
Mary Ann CheathamDepartment of Communication Sciences and Disorders, Northwestern University, Evanston, Illinois 60208.ORCID 0000-0002-4461-3146
Kazuaki HommaDepartment of Otolaryngology - Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 k-homma@northwestern.edu.ORCID 0000-0002-4440-2277

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
Defining the pathological mechanisms of hereditary hearing lossR01DC017482 · NIDCD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HOMMA, KAZUAKI · 2019 to 2023
$1.7M
NCI NIH HHS P30 CA060553NIDCD NIH HHS R01 DC017482
6 · The paper itself

Abstract

Prestin's voltage-driven motor activity confers sound-elicited somatic electromotility on auditory outer hair cells (OHCs) and is essential for the exquisite sensitivity and frequency selectivity of mammalian hearing. Lack of prestin results in ∼50 dB hearing threshold shifts across frequency, supporting the causal association of the prestin-coding gene,

Indexed as

Epilepsy, ReflexHearing LossMolecular Motor ProteinsSulfate TransportersAnimalsFemaleHair Cells, Auditory, OuterMaleMiceMice, Inbred C57BLMice, TransgenicMutation, MissenseMolecular Motor ProteinsPres protein, mouseSulfate Transportersaudiogenic seizurecochlear amplificationDFNB61electromotilityhereditary hearing lossprestinSLC26A5

Identifiers

PMID40555520
PMCPMC12311761

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.