Evidence map›Paper›PMID 40555359›Full record

ArticleNature2025

Structural and functional characterization of human sweet taste receptor.

Zongjun Shi, Weixiu Xu, Lijie Wu, Xiaolei Yue, Shenhui Liu, Wei Ding, Jinyi Zhang, Bing Meng, Lianghao Zhao, Xiaoyan Liu and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Correlative Imaging Platform Linking Taste Cell Function to Molecular Identity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Molecular Dynamics Insights into TAS1R2 Transmembrane Domain Activation.International journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zongjun Shi *iHuman Institute, ShanghaiTech University, Shanghai, China.ORCID 0009-0000-6292-6093
Weixiu Xu *iHuman Institute, ShanghaiTech University, Shanghai, China.
Lijie Wu *iHuman Institute, ShanghaiTech University, Shanghai, China.ORCID 0000-0002-2253-0497
Xiaolei Yue *iHuman Institute, ShanghaiTech University, Shanghai, China.
Shenhui LiuiHuman Institute, ShanghaiTech University, Shanghai, China.
Wei DingBeijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China.
Jinyi ZhangiHuman Institute, ShanghaiTech University, Shanghai, China.
Bing MengiHuman Institute, ShanghaiTech University, Shanghai, China.ORCID 0000-0001-9076-2946
Lianghao ZhaoiHuman Institute, ShanghaiTech University, Shanghai, China.
Xiaoyan LiuiHuman Institute, ShanghaiTech University, Shanghai, China.
Junlin LiuiHuman Institute, ShanghaiTech University, Shanghai, China.
Zhi-Jie LiuiHuman Institute, ShanghaiTech University, Shanghai, China. liuzhj@shanghaitech.edu.cn.ORCID 0000-0001-7279-2893
Tian HuaiHuman Institute, ShanghaiTech University, Shanghai, China. huatian@shanghaitech.edu.cn.ORCID 0000-0002-6132-2068

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sweet taste perception influences dietary choices and metabolic health. The human sweet taste receptor, a class C G-protein-coupled receptor (GPCR) heterodimer composed of TAS1R2 and TAS1R3 (refs.

Indexed as

Receptors, G-Protein-CoupledSweetening AgentsTasteApoproteinsBinding SitesCryoelectron MicroscopyHumansLigandsModels, MolecularMolecular Dynamics SimulationProtein BindingProtein DomainsProtein MultimerizationSignal TransductionSucroseApoproteinsLigandsReceptors, G-Protein-CoupledSucroseSweetening Agentstaste receptors, type 1trichlorosucrose

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.