ArticlePloS one2025
Health-Related Quality of Life measured with EQ-5D-5L among tuberculosis patients in Addis Ababa, Ethiopia: Institutional-based cross-sectional study.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Factors influencing quality of life in patients with pulmonary tuberculosis: a protocol for a systematic review and meta-analysis.BMJ open · 2026Article
- Real-World Before-After Study ofNutrients · 2026Article
- Health-related quality of life and associated factors among adult tuberculosis patients in Kembata Zone, Southern Ethiopia: a mixed-methods cross-sectional study.BMC infectious diseases · 2026Article
- Assessing inequalities in health utility scores among cancer patients undergoing systemic and radiation therapy.Health and quality of life outcomes · 2025Article
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Abstract
backgroundTuberculosis (TB) substantially compromises health-related quality of life (HRQoL), yet limited studies have assessed its impact on Ethiopian patients using the EQ-5D instrument. This study evaluates HRQoL, estimates health state utility values, and identifies associated factors among TB patients in Ethiopia.
methodsA cross-sectional study was conducted across 20 public health centers in Addis Ababa, Ethiopia, involving 672 TB patients selected via proportional allocation. HRQoL was measured using the EuroQol five-dimension five-level (EQ-5D-5L) tool. Predictors of utility scores were analyzed using the Kruskal-Wallis test and Tobit censored regression models.
resultsAnxiety/depression was the most frequently affected dimension (55.4% of participants). The mean EQ-5D-5L utility score was 0.91 (SD ± 0.14), and the mean EQ-VAS score was 80.6 (SD ± 15.6). Older age (55-64 years: β = -0.067, p < 0.001; ≥ 65 years: β = -0.383, p < 0.001) and unemployment (β = -0.119, p < 0.001) were associated with significantly lower HRQoL. Conversely, higher income (β = 0.056, p < 0.001), absence of comorbidities (β = 0.059, p < 0.001), and mid-treatment duration (4-5 months: β = 0.029, p = 0.011) correlated with better HRQoL.
conclusionThe findings underscore the influence of socio-demographic and clinical factors on HRQoL among TB patients in Ethiopia, calling for targeted interventions and policy reforms to enhance treatment outcomes and patient support.
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