ArticlePloS one2025
Association between serum zinc and serum neurofilament light chains: A population-based analysis.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- TyG Index and Obesity-Related Measures in Relation to All-Cause Mortality Among HSV-Positive Adults.International journal of endocrinology · 2026Article
- The Nonlinear Relationship Between the Aggregate Index of Systemic Inflammation and Serum Neurofilament Light Chain Levels in U.S. Adults: A Cross-Sectional Study.Mediators of inflammation · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile serum zinc levels are strongly associated with various neurological disorders, the relationship between serum zinc and axonal damage remains largely unexplored. Consequently, the objective of this study was to investigate whether an association exists between serum zinc levels and serum neurofilament light chain (sNfL) concentrations in the general population.
methodsData from the National Health and Nutrition Examination Survey (NHANES) conducted during 2013-2014 were utilized for this study. We applied multiple linear regression and smoothed curve fitting methods to explore the connection between serum zinc levels and sNfL. Furthermore, subgroup analyses and interaction tests were performed to assess the consistency of this association among various populations.
resultsThis analysis included a total of 585 adults. After controlling for various confounding variables, we identified a significant negative association between serum zinc levels and sNfL (β = -0.62, 95% CI: -1.18, -0.05, p = 0.0321). Stratified analyses revealed that this negative association was significant only among individuals who were divorced, widowed, or separated, with no such association observed in other subgroups. This finding suggests that serum zinc levels may have a more pronounced impact on neurological health within these specific populations. Additionally, we identified an L-shaped association between serum zinc and sNfL, with an inflection point at 10.21 nmol/L.
conclusionOur findings demonstrate an inverse association between serum zinc levels and sNfL concentrations among adults in the United States. This relationship is particularly pronounced in individuals who are divorced, widowed, or separated.
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