Evidence map›Paper›PMID 40554221›Full record

ArticleBiomaterials2026

The development of a collagen-nanoscale hydroxyapatite three-dimensional (3D) in vitro culture system for reproducing osteocyte differentiation and tissue mineralization.

Xiaoyu Xu, Brian T Golz, Brennan T Flannery, Maxime A Gallant, Whitney A Bullock, Teresita M Bellido, Eric A Nauman, Sherry L Voytik-Harbin, Dianne Little, Russell P Main

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaoyu XuWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA; Musculoskeletal Biology and Mechanics Lab, Purdue University, West Lafayette, IN, USA. Electronic address: xiaoyu.xu@pennmedicine.upenn.edu.
Brian T GolzWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA; Musculoskeletal Biology and Mechanics Lab, Purdue University, West Lafayette, IN, USA. Electronic address: btgolz1@gmail.com.
Brennan T FlanneryWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA. Electronic address: bxf169@case.edu.
Maxime A GallantMusculoskeletal Biology and Mechanics Lab, Purdue University, West Lafayette, IN, USA. Electronic address: maxgallant79@gmail.com.
Whitney A BullockMusculoskeletal Biology and Mechanics Lab, Purdue University, West Lafayette, IN, USA; Department of Biology, Natural Sciences Collegium, Eckerd College, Saint Petersburg, FL, USA. Electronic address: bullockwa@eckerd.edu.
Teresita M BellidoUniversity of Arkansas for Medical Science, College of Medicine, Department of Physiology and Cell Biology, Little Rock, AR, USA. Electronic address: tmbellido@uams.edu.
Eric A NaumanWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA; School of Mechanical Engineering, Purdue University, West Lafayette, IN, USA; Department of Biomedical Engineering, College of Engineering and Applied Sciences, University of Cincinnati, Cincinnati, OH, USA. Electronic address: naumanea@ucmail.uc.edu.
Sherry L Voytik-HarbinWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA. Electronic address: harbins@purdue.edu.
Dianne LittleWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA; Department of Basic Medical Sciences, Purdue University, West Lafayette, IN, USA. Electronic address: little33@purdue.edu.
Russell P MainWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA; Musculoskeletal Biology and Mechanics Lab, Purdue University, West Lafayette, IN, USA; Department of Basic Medical Sciences, Purdue University, West Lafayette, IN, USA.

Funding

A 3D co-culture system for examining osteocyte-osteoblast interactions and responR21AR065659 · NIAMS · PURDUE UNIVERSITY · PI MAIN, RUSSELL P · 2014 to 2015
$385k
NIAMS NIH HHS R21 AR065659
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

3D in vitro cultureCollagen-mineral matrixMatrix stiffnessOsteocyte differentiationRT-qPCRSOSTTissue mineralization

Identifiers

PMID40554221
PMCPMC13307556

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.