ArticleIndian heart journal
Exploring the role of left atrial fibrosis and left atrial volume index through cardiac magnetic resonance imaging in embolic stroke of undetermined source: A network meta-analysis.
Article in Indian heart journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Association of Left Atrial Echocardiographic Indices With Atrial Fibrillation in Cryptogenic Stroke: A Systematic Review and Meta-Analysis.Echocardiography (Mount Kisco, N.Y.) · 2026Pooled it
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesLeft atrial fibrosis (LAF) and left atrial volume index (LAVI), assessed via cardiac magnetic resonance (CMR), are emerging biomarkers for atrial cardiomyopathy and stroke risk. Their roles in the embolic stroke of undetermined source (ESUS) remain unclear. This study evaluates LAF and LAVI in ESUS and explores whether age modifies these outcomes.
methodsFollowing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (PROSPERO CRD42024615479), we searched eight databases (inception-October 2024) for studies evaluating LAF or LAVI via CMR in ESUS, compared to atrial fibrillation (AF) without stroke, cardioembolic stroke (CES), non-cardioembolic stroke (NCE), and healthy controls. We performed a Bayesian network meta-analysis to estimate mean differences (MD) with 95 % credible intervals (CrI). Node-splitting tested consistency, and a meta-regression examined the effect of age.
resultsTen observational studies with 1285 patients (mean age 65.1 ± 12.1 years) were included, demonstrating a generally low risk of bias. ESUS patients had significantly higher LAF than healthy controls (MD 9.86 %, 95 % CrI 3.05 %-16.62 %). No significant LAF differences were found between ESUS and AF without stroke, CES, or NCE. LAVI did not differ significantly between ESUS and any comparator groups. Node-splitting indicated no inconsistencies. Age was not significantly associated with LAF or LAVI.
conclusionESUS patients show increased LAF compared to healthy individuals, suggesting a key role of LAF in ESUS pathogenesis. Nonetheless, the application of CMR-detected LAF as a prognostic biomarker requires prospective validation to confirm its clinical utility in predicting stroke recurrence.
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