Evidence map›Paper›PMID 40553695›Full record

ArticleThe Annals of thoracic surgery2026

Safety and Immediate Efficacy of Pulmonary Thromboendarterectomy for Chronic Thromboembolic Disease.

Elizabeth M Bird, Jenny Z Yang, Edward W Mims, Kim M Kerr, Demosthenes G Papamatheakis, David S Poch, Peter F Fedullo, Atul Malhotra, Lori B Daniels, Anna McDivit-Mizzell and 5 more

Abstract read
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In one paragraph

Article in The Annals of thoracic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Elizabeth M BirdUniversity of California San Diego School of Medicine, La Jolla, California; Division of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, La Jolla, California.
Jenny Z YangDivision of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, La Jolla, California.
Edward W MimsDivision of Pulmonary and Critical Care Medicine, University of Texas Southwestern, Dallas, Texas.
Kim M KerrDivision of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, La Jolla, California.
Demosthenes G PapamatheakisDivision of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, La Jolla, California.
David S PochDivision of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, La Jolla, California.
Peter F FedulloDivision of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, La Jolla, California.
Atul MalhotraDivision of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, La Jolla, California.
Lori B DanielsDivision of Cardiovascular Medicine, University of California San Diego, La Jolla, California.
Anna McDivit-MizzellDivision of Cardiovascular Medicine, University of California San Diego, La Jolla, California.
Nicholas PhreanerDivision of Cardiovascular Medicine, University of California San Diego, La Jolla, California.
Nick H KimDivision of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, La Jolla, California.
Victor G PretoriusDivision of Cardiovascular and Thoracic Surgery, University of California San Diego, La Jolla, California.
Michael M MadaniDivision of Cardiovascular and Thoracic Surgery, University of California San Diego, La Jolla, California.
Timothy M FernandesDivision of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, La Jolla, California. Electronic address: tfernandes@health.ucsd.edu.

Funding

Is Obstructive Sleep Apnea Important in the Development of Alzheimer's DiseaseR01AG063925 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2020 to 2024
$3.7M
Underlying mechanisms of obesity-induced obstructive sleep apneaR01HL148436 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2020 to 2026
$3.4M
Sleep Apnea Endophenotypes: One Size Does Not Fit AllR01HL154926 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2021 to 2025
$3.3M
The cardiovascular consequences of sleep apnea plus COPD (Overlap syndrome)R01HL166485 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2023 to 2026
$3.1M
VentNet: A Real-Time Multimodal Data Integration Model for Prediction of Respiratory Failure in Patients with COVID-19R01HL157985 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, NEMATI, SHAMIM · 2022 to 2025
$2.9M
Developing a Diverse Next Generation of Leaders in Respiratory ScienceT32HL166127 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Laura Elise Crotty Alexander, Atul Malhotra · 2023 to 2026
$1.6M
NHLBI NIH HHS R01 HL148436NHLBI NIH HHS R01 HL154926NHLBI NIH HHS R01 HL157985NHLBI NIH HHS R01 HL166485NHLBI NIH HHS T32 HL166127NIA NIH HHS R01 AG063925
6 · The paper itself

Abstract

backgroundChronic thromboembolic disease (CTED) is characterized by pulmonary vascular thromboembolic occlusions without elevation in pulmonary artery pressures or pulmonary vascular resistance at rest. Many patients have dyspnea on exertion despite normal resting hemodynamics and symptomatic improvement after pulmonary thromboendarterectomy surgery. We hypothesize that the safety and efficacy of pulmonary thromboendarterectomy in CTED will be similar to that in chronic thromboembolic pulmonary hypertension (CTEPH), which currently has a better characterized risk-benefit profile.

methodsPatients who underwent pulmonary thromboendarterectomy for CTED from 2009 through 2022 had preoperative and postoperative pulmonary hemodynamics and postoperative course (n = 163) compared with a reference CTEPH cohort who underwent pulmonary thromboendarterectomy from 2017 to 2022 (n = 870). Preoperative rest hemodynamics were compared with both preoperative exercise and postoperative rest hemodynamics in patients with CTED who had measurements for all 3 conditions.

resultsThe CTED cohort had 99 patients with complete preoperative rest, preoperative exercise, and postoperative hemodynamic measurements. Mean pulmonary artery pressure, pulmonary vascular resistance, and pulmonary artery compliance all changed abnormally with preoperative exercise but improved after surgery (21 [SD, 4], 36 [SD, 10], 18 [interquartile range {IQR}15-21] mm Hg; 175 [SD, 87], 205 [SD, 149], 126 [SD, 55] dyne·s·cm

conclusionsPulmonary thromboendarterectomy is safe and well-tolerated in patients with CTED, improving pulmonary hemodynamics and pulmonary artery compliance.

Indexed as

EndarterectomyPulmonary ArteryPulmonary EmbolismAgedChronic DiseaseFemaleHemodynamicsHumansHypertension, PulmonaryMaleMiddle AgedRetrospective StudiesTime FactorsTreatment OutcomeVascular Resistance

Identifiers

PMID40553695
PMCPMC12538298

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.